Description: Homo sapiens RAP1A, member of RAS oncogene family (RAP1A), transcript variant 2, mRNA. RefSeq Summary (NM_002884): This gene encodes a member of the Ras family of small GTPases. The encoded protein undergoes a change in conformational state and activity, depending on whether it is bound to GTP or GDP. This protein is activated by several types of guanine nucleotide exchange factors (GEFs), and inactivated by two groups of GTPase-activating proteins (GAPs). The activation status of the encoded protein is therefore affected by the balance of intracellular levels of GEFs and GAPs. The encoded protein regulates signaling pathways that affect cell proliferation and adhesion, and may play a role in tumor malignancy. Pseudogenes of this gene have been defined on chromosomes 14 and 17. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]. Transcript (Including UTRs) Position: hg19 chr1:112,162,405-112,256,101 Size: 93,697 Total Exon Count: 8 Strand: + Coding Region Position: hg19 chr1:112,233,983-112,251,857 Size: 17,875 Coding Exon Count: 6
ID:RAP1A_HUMAN DESCRIPTION: RecName: Full=Ras-related protein Rap-1A; AltName: Full=C21KG; AltName: Full=G-22K; AltName: Full=GTP-binding protein smg p21A; AltName: Full=Ras-related protein Krev-1; Flags: Precursor; FUNCTION: Induces morphological reversion of a cell line transformed by a Ras oncogene. Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner. ENZYME REGULATION: Activated by guanine nucleotide-exchange factors (GEF) EPAC and EPAC2 in a cAMP-dependent manner, and GFR. SUBUNIT: In its GTP-bound form interacts with PLCE1 and RADIL. Interacts with SGSM1, SGSM2 and SGSM3. INTERACTION: P04049:RAF1; NbExp=2; IntAct=EBI-491414, EBI-365996; Q8WWW0-2:RASSF5; NbExp=3; IntAct=EBI-491414, EBI-960502; Q5EBH1:Rassf5 (xeno); NbExp=2; IntAct=EBI-491414, EBI-960530; SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor. SIMILARITY: Belongs to the small GTPase superfamily. Ras family. SEQUENCE CAUTION: Sequence=CAB55685.2; Type=Erroneous gene model prediction; WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/RAP1AID272.html";
Blood Pressure Daniel Levy et al. BMC medical genetics 2007, Framingham Heart Study 100K Project: genome-wide associations for blood pressure and arterial stiffness., BMC medical genetics.
[PubMed 17903302]
These results of genome-wide association testing for blood pressure and arterial stiffness phenotypes in an unselected community-based sample of adults may aid in the identification of the genetic basis of hypertension and arterial disease, help identify high risk individuals, and guide novel therapies for hypertension. Additional studies are needed to replicate any associations identified in these analyses.
Echocardiography Ramachandran S Vasan et al. BMC medical genetics 2007, Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study., BMC medical genetics.
[PubMed 17903301]
In hypothesis-generating GWAS of echocardiography, ETT and BA vascular function in a moderate-sized community-based sample, we identified several SNPs that are candidates for replication attempts and we provide a web-based GWAS resource for the research community.
Lipoproteins, VLDL Sekar Kathiresan et al. BMC medical genetics 2007, A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study., BMC medical genetics.
[PubMed 17903299]
Using a 100K genome-wide scan, we have generated a set of putative associations for common sequence variants and lipid phenotypes. Validation of selected hypotheses in additional samples did not identify any new loci underlying variability in blood lipids. Lack of replication may be due to inadequate statistical power to detect modest quantitative trait locus effects (i.e., <1% of trait variance explained) or reduced genomic coverage of the 100K array. GWAS in FHS using a denser genome-wide genotyping platform and a better-powered replication strategy may identify novel loci underlying blood lipids.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P62834
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0007165 signal transduction GO:0007264 small GTPase mediated signal transduction GO:0007399 nervous system development GO:0009743 response to carbohydrate GO:0010976 positive regulation of neuron projection development GO:0015031 protein transport GO:0032486 Rap protein signal transduction GO:0032966 negative regulation of collagen biosynthetic process GO:0035690 cellular response to drug GO:0038180 nerve growth factor signaling pathway GO:0043312 neutrophil degranulation GO:0043547 positive regulation of GTPase activity GO:0045860 positive regulation of protein kinase activity GO:0046326 positive regulation of glucose import GO:0050796 regulation of insulin secretion GO:0061028 establishment of endothelial barrier GO:0070374 positive regulation of ERK1 and ERK2 cascade GO:0071320 cellular response to cAMP GO:0071333 cellular response to glucose stimulus GO:0071407 cellular response to organic cyclic compound GO:0097327 response to antineoplastic agent GO:0097421 liver regeneration GO:1901888 regulation of cell junction assembly GO:1905451 positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis GO:1990090 cellular response to nerve growth factor stimulus GO:2000301 negative regulation of synaptic vesicle exocytosis GO:2001214 positive regulation of vasculogenesis GO:0030033 microvillus assembly
KJ891980 - Synthetic construct Homo sapiens clone ccsbBroadEn_01374 RAP1A gene, encodes complete protein. E02296 - DNA encoding cancer suppressor gene Krev-1. M22995 - Human ras-related protein (Krev-1) mRNA, complete cds. BC014086 - Homo sapiens RAP1A, member of RAS oncogene family, mRNA (cDNA clone MGC:20027 IMAGE:4422971), complete cds. AK293044 - Homo sapiens cDNA FLJ75985 complete cds, highly similar to Homo sapiens RAP1A, member of RAS oncogene family (RAP1A), transcript variant 2, mRNA. X12533 - Human rap1A mRNA for ras-related protein. EU831467 - Synthetic construct Homo sapiens clone HAIB:100066496; DKFZo008F0917 RAP1A, member of RAS oncogene family protein (RAP1A) gene, encodes complete protein. EU831554 - Synthetic construct Homo sapiens clone HAIB:100066583; DKFZo004F0918 RAP1A, member of RAS oncogene family protein (RAP1A) gene, encodes complete protein. AB464127 - Synthetic construct DNA, clone: pF1KB6804, Homo sapiens RAP1A gene for RAP1A, member of RAS oncogene family, without stop codon, in Flexi system. AB451360 - Homo sapiens RAP1A mRNA for Ras-related protein Rap-1A precursor, partial cds, clone: FLJ08033AAAF. AB451235 - Homo sapiens RAP1A mRNA for Ras-related protein Rap-1A precursor, complete cds, clone: FLJ08033AAAN. AF493912 - Homo sapiens Ras family small GTP binding protein RAP1A (RAP1A) mRNA, complete cds. BT019666 - Homo sapiens RAP1A, member of RAS oncogene family mRNA, complete cds. JD296739 - Sequence 277763 from Patent EP1572962. JD155389 - Sequence 136413 from Patent EP1572962. JD093979 - Sequence 75003 from Patent EP1572962.