Human Gene POLR2E (uc002lre.4)
  Description: Homo sapiens polymerase (RNA) II (DNA directed) polypeptide E, 25kDa (POLR2E), mRNA.
RefSeq Summary (NM_002695): This gene encodes the fifth largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit is shared by the other two DNA-directed RNA polymerases and is present in two-fold molar excess over the other polymerase subunits. An interaction between this subunit and a hepatitis virus transactivating protein has been demonstrated, suggesting that interaction between transcriptional activators and the polymerase can occur through this subunit. A pseudogene is located on chromosome 11. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2015].
Transcript (Including UTRs)
   Position: hg19 chr19:1,086,578-1,095,391 Size: 8,814 Total Exon Count: 8 Strand: -
Coding Region
   Position: hg19 chr19:1,089,485-1,095,314 Size: 5,830 Coding Exon Count: 7 

Page IndexSequence and LinksUniProtKB CommentsPrimersGenetic AssociationsMalaCards
CTDGene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein Structure
Other SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther NamesModel Information
Methods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:1,086,578-1,095,391)mRNA (may differ from genome)Protein (210 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDLynxMalacards
MGIneXtProtOMIMPubMedReactomeTreefam
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: RPAB1_HUMAN
DESCRIPTION: RecName: Full=DNA-directed RNA polymerases I, II, and III subunit RPABC1; Short=RNA polymerases I, II, and III subunit ABC1; AltName: Full=DNA-directed RNA polymerase II 23 kDa polypeptide; AltName: Full=DNA-directed RNA polymerase II subunit E; AltName: Full=RPB5 homolog; AltName: Full=XAP4;
FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2E/RPB5 is part of the lower jaw surrounding the central large cleft and thought to grab the incoming DNA template. Seems to be the major component in this process (By similarity).
SUBUNIT: Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes consisting of at least 13, 12 and 17 subunits, respectively (By similarity). In RNA Pol II, this subunit is present in 2-fold molar excess over the other subunits. Interacts with URI1. Interacts with HBV protein X.
INTERACTION: O94763:URI1; NbExp=2; IntAct=EBI-395189, EBI-357067;
SUBCELLULAR LOCATION: Nucleus.
SIMILARITY: Belongs to the archaeal RpoH/eukaryotic RPB5 RNA polymerase subunit family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): POLR2E
CDC HuGE Published Literature: POLR2E

-  MalaCards Disease Associations
  MalaCards Gene Search: POLR2E
Diseases sorted by gene-association score: myasthenic syndrome, congenital, 5 (4)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 80.81 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 2822.73 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -40.7077-0.529 Picture PostScript Text
3' UTR -914.212156-0.424 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR014381 - DNA-dir_RNA_pol_RPB5_su
IPR005571 - RNA_pol_Rpb5_N
IPR000783 - RNA_pol_subH/Rpb5_C
IPR020608 - RNA_pol_subH/Rpb5_CS

Pfam Domains:
PF01191 - RNA polymerase Rpb5, C-terminal domain
PF03871 - RNA polymerase Rpb5, N-terminal domain

SCOP Domains:
53036 - Eukaryotic RPB5 N-terminal domain
55287 - RPB5-like RNA polymerase subunit

ModBase Predicted Comparative 3D Structure on P19388
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserGenome BrowserGenome BrowserGenome BrowserGenome Browser
Gene DetailsGene Details Gene DetailsGene DetailsGene Details
Gene SorterGene Sorter Gene SorterGene SorterGene Sorter
 RGDEnsemblFlyBaseWormBaseSGD
 Protein SequenceProtein SequenceProtein SequenceProtein SequenceProtein Sequence
 AlignmentAlignmentAlignmentAlignmentAlignment

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0005515 protein binding
GO:0001054 RNA polymerase I activity
GO:0001055 RNA polymerase II activity
GO:0001056 RNA polymerase III activity

Biological Process:
GO:0000398 mRNA splicing, via spliceosome
GO:0006283 transcription-coupled nucleotide-excision repair
GO:0006351 transcription, DNA-templated
GO:0006361 transcription initiation from RNA polymerase I promoter
GO:0006363 termination of RNA polymerase I transcription
GO:0006366 transcription from RNA polymerase II promoter
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0006368 transcription elongation from RNA polymerase II promoter
GO:0006370 7-methylguanosine mRNA capping
GO:0006383 transcription from RNA polymerase III promoter
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0016032 viral process
GO:0016070 RNA metabolic process
GO:0042795 snRNA transcription from RNA polymerase II promoter
GO:0045815 positive regulation of gene expression, epigenetic
GO:0060964 regulation of gene silencing by miRNA

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005665 DNA-directed RNA polymerase II, core complex
GO:0005666 DNA-directed RNA polymerase III complex
GO:0005736 DNA-directed RNA polymerase I complex
GO:0005829 cytosol


-  Descriptions from all associated GenBank mRNAs
  JD061936 - Sequence 42960 from Patent EP1572962.
JD140928 - Sequence 121952 from Patent EP1572962.
JD036749 - Sequence 17773 from Patent EP1572962.
BC034144 - Homo sapiens polymerase (RNA) II (DNA directed) polypeptide E, 25kDa, mRNA (cDNA clone MGC:32760 IMAGE:4617000), complete cds.
D38251 - Homo sapiens mRNA for RPB5 (XAP4), complete cds.
BC004441 - Homo sapiens polymerase (RNA) II (DNA directed) polypeptide E, 25kDa, mRNA (cDNA clone MGC:4035 IMAGE:2820565), complete cds.
J04965 - Human RNA polymerase II 23kD subunit (POLR2) mRNA, complete cds.
AK122813 - Homo sapiens cDNA FLJ16409 fis, clone BLADE2002972, highly similar to DNA-DIRECTED RNA POLYMERASE II 23 KDA POLYPEPTIDE (EC 2.7.7.6).
JD050908 - Sequence 31932 from Patent EP1572962.
AK295975 - Homo sapiens cDNA FLJ55074 complete cds, highly similar to DNA-directed RNA polymerase II 23 kDa polypeptide (EC 2.7.7.6).
JD210875 - Sequence 191899 from Patent EP1572962.
JD115537 - Sequence 96561 from Patent EP1572962.
JD392320 - Sequence 373344 from Patent EP1572962.
JD057474 - Sequence 38498 from Patent EP1572962.
JD210271 - Sequence 191295 from Patent EP1572962.
JD252912 - Sequence 233936 from Patent EP1572962.
JD535692 - Sequence 516716 from Patent EP1572962.
JD179943 - Sequence 160967 from Patent EP1572962.
LF208810 - JP 2014500723-A/16313: Polycomb-Associated Non-Coding RNAs.
JD052254 - Sequence 33278 from Patent EP1572962.
AK312625 - Homo sapiens cDNA, FLJ93009, Homo sapiens polymerase (RNA) II (DNA directed) polypeptide E,25kDa (POLR2E), mRNA.
HQ448367 - Synthetic construct Homo sapiens clone IMAGE:100071791; CCSB003826_02 polymerase (RNA) II (DNA directed) polypeptide E, 25kDa (POLR2E) gene, encodes complete protein.
KJ891845 - Synthetic construct Homo sapiens clone ccsbBroadEn_01239 POLR2E gene, encodes complete protein.
S42643 - RNA polymerase II [human, mRNA, 144 nt].
AB464042 - Synthetic construct DNA, clone: pF1KB8264, Homo sapiens POLR2E gene for polymerase (RNA) II (DNA directed) polypeptide E, 25kDa, without stop codon, in Flexi system.
LF323069 - JP 2014500723-A/130572: Polycomb-Associated Non-Coding RNAs.
LF323072 - JP 2014500723-A/130575: Polycomb-Associated Non-Coding RNAs.
JD211263 - Sequence 192287 from Patent EP1572962.
MA558646 - JP 2018138019-A/130572: Polycomb-Associated Non-Coding RNAs.
MA558649 - JP 2018138019-A/130575: Polycomb-Associated Non-Coding RNAs.
MA444387 - JP 2018138019-A/16313: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa00230 - Purine metabolism
hsa00240 - Pyrimidine metabolism
hsa01100 - Metabolic pathways
hsa03020 - RNA polymerase
hsa05016 - Huntington's disease

Reactome (by CSHL, EBI, and GO)

Protein P19388 (Reactome details) participates in the following event(s):

R-HSA-73865 Assembly of RNA Polymerase I Holoenzyme (human)
R-HSA-73757 Binding of RRN3 to RNA Polymerase I
R-HSA-5250947 B-WICH complex binds rDNA promoter
R-HSA-76056 Recruitment of RNA polymerase III to TFIIIB:TFIIIC:TFIIIA:Type 1 Promoter Complex
R-HSA-83803 Recruitment of RNA Polymerase III to TFIIIB:SNAPc:Type 3 Promoter Complex
R-HSA-83805 Recruitment of RNA Polymerase III to the TFIIIB:TFIIIC: Type 2 Promoter Complex
R-HSA-113454 RNA Polymerase III Termination and release of transcribed RNA
R-HSA-113429 Elongating transcript encounters a lesion in the template
R-HSA-5578742 AGO1,2:small RNA complexes interact with chromatin
R-HSA-6810238 RNA polymerase II binds initiation factors at promoter of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12)
R-HSA-73758 Recruitment of Active RNA Polymerase I to SL1:phos.UBF-1:rDNA Promoter
R-HSA-74994 Polymerase I Transcription Complex/Nascent Pre rRNA Complex pauses at the TTF-I:Sal Box
R-HSA-73769 Loss of Rrn3 from RNA Polymerase I promoter escape complex
R-HSA-74992 Dissociation of PTRF:Polymerase I/Nascent Pre rRNA Complex:TTF-I:Sal Box
R-HSA-5250930 B-WICH recruits histone acetyltransferases
R-HSA-76060 RNA Polymerase III Promoter Opening at Type 1 Promoters
R-HSA-112150 RNA Polymerase III Promoter Opening at Type 2 Promoters
R-HSA-112152 RNA Polymerase III Promoter Opening at Type 3 Promoters
R-HSA-112055 RNA Polymerase III Abortive Initiation At Type 1 Open Promoters
R-HSA-112153 RNA Polymerase III Simple Start Sequence Initiation At Type 1 Promoters
R-HSA-112149 RNA Polymerase III Abortive Initiation At Type 2 Open Promoters
R-HSA-112155 RNA Polymerase III Simple Start Sequence Initiation At Type 2 Promoters
R-HSA-112054 RNA Polymerase III Abortive Initiation At Type 3 Open Promoters
R-HSA-112156 RNA Polymerase III Simple Start Sequence Initiation At Type 3 Promoters
R-HSA-113442 RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites
R-HSA-113446 Initiation of RNA Polymerase III Productive Transcription
R-HSA-113449 RNA Polymerase III Transcriptional Pause at Terminator Sequence
R-HSA-113451 Resumption of RNA Polymerase III Productive Transcription
R-HSA-113705 RNA Polymerase III Productive Transcription
R-HSA-112395 Abortive termination of elongation after arrest
R-HSA-167459 Abortive termination of HIV-1 elongation after arrest (Tat-containing elongation complex)
R-HSA-167481 Abortive termination of HIV-1 elongation after arrest
R-HSA-6781840 ERCC6 binds stalled RNA Pol II
R-HSA-109638 Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex
R-HSA-73946 Abortive initiation
R-HSA-75856 Abortive Initiation Before Second Transition
R-HSA-75891 Abortive Initiation After Second Transition
R-HSA-167468 Abortive HIV-1 Initiation After Second Transition
R-HSA-167474 Abortive HIV-1 Initiation Before Second Transition
R-HSA-167477 Abortive HIV-1 initiation after formation of the first phosphodiester bond
R-HSA-113407 DSIF complex binds to RNA Pol II (hypophosphorylated)
R-HSA-112383 Hypophosphorylation of RNA Pol II CTD by FCP1P protein
R-HSA-167083 DSIF complex binds to RNA Pol II (hypophosphorylated)
R-HSA-167072 Hypophosphorylation of RNA Pol II CTD by FCP1P protein
R-HSA-9012315 ESR1:ESTG:P-TEFb recruited to paused RNA polymerase II on MYB gene
R-HSA-9012319 p-TEFb phosphorylates serine 2 in RNA polymerase II CTD
R-HSA-6782211 DNA polymerases delta, epsilon or kappa bind the TC-NER site
R-HSA-6782204 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER
R-HSA-6782224 3' incision by ERCC5 (XPG) in TC-NER
R-HSA-6782227 Ligation of newly synthesized repair patch to incised DNA in TC-NER
R-HSA-6782208 Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER
R-HSA-6810235 RPAP2 binds RNA polymerase II phosphorylated at serine-7 residues of heptad repeats in the C-terminal domain
R-HSA-6810233 CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter
R-HSA-74993 PTRF Binds the Polymerase I Transcription Complex/Nascent Pre rRNA Complex paused at the TTF-I:Sal Box
R-HSA-74986 Elongation of pre-rRNA transcript
R-HSA-427366 Transcription of intergenic spacer of the rRNA gene
R-HSA-112379 Recruitment of elongation factors to form elongation complex
R-HSA-112381 Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex
R-HSA-113411 2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing
R-HSA-113412 Pol II elongation complex moves on the template as transcript elongates
R-HSA-113414 7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest
R-HSA-112385 Addition of nucleotides leads to transcript elongation
R-HSA-112392 Resumption of elongation after recovery from pausing
R-HSA-113413 TFIIS-mediated recovery of elongation from arrest
R-HSA-112396 Separation of elongating transcript from template
R-HSA-167150 Resumption of elongation of HIV-1 transcript after recovery from pausing
R-HSA-167076 2-4 nt.backtracking of Pol II complex on the HIV-1 template leading to elongation pausing
R-HSA-167077 Recruitment of elongation factors to form HIV-1 elongation complex
R-HSA-167084 Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex
R-HSA-167282 2-4 nt.backtracking of Pol II complex on the HIV-1 template leading to elongation pausing
R-HSA-167284 7-14 nt. Backtracking of Pol II complex on the HIV-1 template leading to elongation arrest
R-HSA-167288 TFIIS-mediated recovery of HIV-1 elongation from arrest
R-HSA-167292 Resumption of elongation of HIV-1 transcript after recovery from pausing
R-HSA-167148 TFIIS-mediated recovery of elongation from arrest
R-HSA-167090 7-14 nt. Backtracking of Pol II complex on the HIV-1 template leading to elongation arrest
R-HSA-170706 Phosphorylation of NEFL by the P-TEFb(Cyclin T1:Cdk9) complex
R-HSA-167191 Hyperphosphorylation (Ser2) of RNA Pol II CTD by the P-TEFb(Cyclin T1:Cdk9) complex
R-HSA-167192 Pol II elongation complex moves on the HIV-1 template as transcript elongates
R-HSA-167181 Addition of nucleotides leads to HIV-1 transcript elongation
R-HSA-167197 Separation of elongating HIV-1 transcript from template
R-HSA-170704 Phosphorylation of DSIF by the P-TEFb(Cyclin T1:Cdk9) complex
R-HSA-167196 Recruitment of elongation factors to form HIV-1 elongation complex
R-HSA-6781833 ERCC8 (CSA) binds stalled RNA Pol II
R-HSA-72103 Formation of pre-mRNPs
R-HSA-75080 Formation of AT-AC A complex
R-HSA-72095 Internal Methylation of mRNA
R-HSA-75873 Addition of Nucleotides 5 through 9 on the growing Transcript
R-HSA-76576 Addition of nucleotides 10 and 11 on the growing transcript: Third Transition
R-HSA-111264 Addition of nucleotides between position +11 and +30
R-HSA-75864 Newly Formed Phosphodiester Bond Stabilized and PPi Released
R-HSA-75866 Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP
R-HSA-75095 Binding of TFIIE to the growing preinitiation complex
R-HSA-75861 NTP Binds Active Site of RNA Polymerase II
R-HSA-75862 Fall Back to Closed Pre-initiation Complex
R-HSA-75949 RNA Polymerase II Promoter Opening: First Transition
R-HSA-113430 Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex
R-HSA-77071 Phosphorylation (Ser5) of RNA pol II CTD
R-HSA-167117 Addition of nucleotides 10 and 11 on the growing HIV-1 transcript: Third Transition
R-HSA-167136 Addition of nucleotides 5 through 9 on the growing HIV-1 transcript
R-HSA-167134 Newly formed phosphodiester bond stabilized and PPi released
R-HSA-167098 Phosphorylation (Ser5) of RNA pol II CTD
R-HSA-167111 Extrusion of 5'-end of 30 nt long HIV-1 transcript through the pore in Pol II complex
R-HSA-167130 Nucleophillic attack by 3'-hydroxyl oxygen of nascent HIV-1 transcript on the Alpha phosphate of NTP
R-HSA-167115 Addition of nucleotides between position +11 and +30 on HIV-1 transcript
R-HSA-167118 NTP binds active site of RNA Polymerase II in HIV-1 open pre-initiation complex
R-HSA-167484 Fall Back to Closed Pre-initiation Complex
R-HSA-167097 HIV Promoter Opening: First Transition
R-HSA-6803523 PTB and hnRNPA1 bind FGFR2 pre-mRNA to repress IIIb splicing and promote formation of FGFR2c mRNA
R-HSA-6803527 ESRP1 and 2 bind FGFR2 pre-mRNA to promote FGFR2b maturation and expression
R-HSA-113402 Formation of DSIF:NELF:early elongation complex
R-HSA-167085 Formation of DSIF:NELF:HIV-1 early elongation complex
R-HSA-77068 Activation of GT
R-HSA-77069 RNA Polymerase II CTD (phosphorylated) binds to CE
R-HSA-77073 SPT5 subunit of Pol II binds the RNA triphosphatase (RTP)
R-HSA-77077 Capping complex formation
R-HSA-156661 Formation of Exon Junction Complex
R-HSA-72143 Lariat Formation and 5'-Splice Site Cleavage
R-HSA-77095 Recognition and binding of the mRNA cap by the cap-binding complex
R-HSA-77090 Methylation of GMP-cap by RNA Methyltransferase
R-HSA-167089 Recognition and binding of the HIV-1 mRNA cap by the cap-binding complex
R-HSA-167133 Activation of GT
R-HSA-167128 RNA Polymerase II CTD (phosphorylated) binds to CE
R-HSA-167153 SPT5 subunit of Pol II binds the RNA triphosphatase (RTP)
R-HSA-6814885 CBCAP complex binds 7-methylguanosine cap of snRNA
R-HSA-5250938 B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9
R-HSA-6797616 CCNK:CDK12 binds RNA Pol II at DNA repair genes
R-HSA-6781867 ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II
R-HSA-72107 Formation of the Spliceosomal E complex
R-HSA-72139 Formation of the active Spliceosomal C (B*) complex
R-HSA-72124 Formation of the Spliceosomal A Complex
R-HSA-72127 Formation of the Spliceosomal B Complex
R-HSA-72130 Formation of an intermediate Spliceosomal C (Bact) complex
R-HSA-75081 Formation of AT-AC B Complex
R-HSA-75082 ATAC spliceosome mediated Lariat formation,5' splice site cleavage
R-HSA-75079 Formation of AT-AC C complex
R-HSA-75083 ATAC spliceosome mediated 3' splice site cleavage, exon ligation
R-HSA-109639 Formation of the closed pre-initiation complex
R-HSA-113409 Abortive termination of early transcription elongation by DSIF:NELF
R-HSA-167087 Limited elongation of the HIV-1 transcript
R-HSA-167478 Abortive termination of HIV-1 early transcription elongation by DSIF:NELF
R-HSA-167147 Separation of abortive HIV-1 transcript from template
R-HSA-77078 Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme
R-HSA-77081 Formation of the CE:GMP intermediate complex
R-HSA-77085 Dissociation of transcript with 5'-GMP from GT
R-HSA-77083 Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA
R-HSA-6782004 Assembly of the pre-incision complex in TC-NER
R-HSA-6797606 CDK12 phosphorylates RNA Pol II CTD at DNA repair genes
R-HSA-6782069 UVSSA:USP7 deubiquitinates ERCC6
R-HSA-6782131 RNA Pol II backtracking in TC-NER
R-HSA-6782138 ERCC5 and RPA bind TC-NER site
R-HSA-6782141 Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER
R-HSA-73762 RNA Polymerase I Transcription Initiation
R-HSA-5250924 B-WICH complex positively regulates rRNA expression
R-HSA-76061 RNA Polymerase III Transcription Initiation From Type 1 Promoter
R-HSA-76071 RNA Polymerase III Transcription Initiation From Type 3 Promoter
R-HSA-76066 RNA Polymerase III Transcription Initiation From Type 2 Promoter
R-HSA-73980 RNA Polymerase III Transcription Termination
R-HSA-749476 RNA Polymerase III Abortive And Retractive Initiation
R-HSA-674695 RNA Polymerase II Pre-transcription Events
R-HSA-6781827 Transcription-Coupled Nucleotide Excision Repair (TC-NER)
R-HSA-5578749 Transcriptional regulation by small RNAs
R-HSA-6781823 Formation of TC-NER Pre-Incision Complex
R-HSA-6807505 RNA polymerase II transcribes snRNA genes
R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogenesis
R-HSA-73854 RNA Polymerase I Promoter Clearance
R-HSA-73863 RNA Polymerase I Transcription Termination
R-HSA-73772 RNA Polymerase I Promoter Escape
R-HSA-5250913 Positive epigenetic regulation of rRNA expression
R-HSA-73780 RNA Polymerase III Chain Elongation
R-HSA-76046 RNA Polymerase III Transcription Initiation
R-HSA-74158 RNA Polymerase III Transcription
R-HSA-167243 Tat-mediated HIV elongation arrest and recovery
R-HSA-167287 HIV elongation arrest and recovery
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-5696398 Nucleotide Excision Repair
R-HSA-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-HSA-167162 RNA Polymerase II HIV Promoter Escape
R-HSA-167161 HIV Transcription Initiation
R-HSA-211000 Gene Silencing by RNA
R-HSA-113418 Formation of the Early Elongation Complex
R-HSA-167158 Formation of the HIV-1 Early Elongation Complex
R-HSA-9018519 Estrogen-dependent gene expression
R-HSA-72163 mRNA Splicing - Major Pathway
R-HSA-5619507 Activation of HOX genes during differentiation
R-HSA-203927 MicroRNA (miRNA) biogenesis
R-HSA-452723 Transcriptional regulation of pluripotent stem cells
R-HSA-5601884 PIWI-interacting RNA (piRNA) biogenesis
R-HSA-6782135 Dual incision in TC-NER
R-HSA-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER
R-HSA-73864 RNA Polymerase I Transcription
R-HSA-1834949 Cytosolic sensors of pathogen-associated DNA
R-HSA-73777 RNA Polymerase I Chain Elongation
R-HSA-427413 NoRC negatively regulates rRNA expression
R-HSA-212165 Epigenetic regulation of gene expression
R-HSA-74160 Gene expression (Transcription)
R-HSA-112382 Formation of RNA Pol II elongation complex
R-HSA-75955 RNA Polymerase II Transcription Elongation
R-HSA-167238 Pausing and recovery of Tat-mediated HIV elongation
R-HSA-167152 Formation of HIV elongation complex in the absence of HIV Tat
R-HSA-167290 Pausing and recovery of HIV elongation
R-HSA-167200 Formation of HIV-1 elongation complex containing HIV-1 Tat
R-HSA-167246 Tat-mediated elongation of the HIV-1 transcript
R-HSA-167172 Transcription of the HIV genome
R-HSA-73894 DNA Repair
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA
R-HSA-72165 mRNA Splicing - Minor Pathway
R-HSA-73776 RNA Polymerase II Promoter Escape
R-HSA-75953 RNA Polymerase II Transcription Initiation
R-HSA-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance
R-HSA-77075 RNA Pol II CTD phosphorylation and interaction with CE
R-HSA-167160 RNA Pol II CTD phosphorylation and interaction with CE during HIV infection
R-HSA-6803529 FGFR2 alternative splicing
R-HSA-8851708 Signaling by FGFR2 IIIa TM
R-HSA-167169 HIV Transcription Elongation
R-HSA-8939211 ESR-mediated signaling
R-HSA-72086 mRNA Capping
R-HSA-72172 mRNA Splicing
R-HSA-1266738 Developmental Biology
R-HSA-168249 Innate Immune System
R-HSA-5250941 Negative epigenetic regulation of rRNA expression
R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes
R-HSA-162599 Late Phase of HIV Life Cycle
R-HSA-8953854 Metabolism of RNA
R-HSA-5654738 Signaling by FGFR2
R-HSA-1839126 FGFR2 mutant receptor activation
R-HSA-167242 Abortive elongation of HIV-1 transcript in the absence of Tat
R-HSA-9006931 Signaling by Nuclear Receptors
R-HSA-168256 Immune System
R-HSA-3700989 Transcriptional Regulation by TP53
R-HSA-162587 HIV Life Cycle
R-HSA-190236 Signaling by FGFR
R-HSA-5655253 Signaling by FGFR2 in disease
R-HSA-162582 Signal Transduction
R-HSA-212436 Generic Transcription Pathway
R-HSA-162906 HIV Infection
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
R-HSA-1226099 Signaling by FGFR in disease
R-HSA-5663205 Infectious disease
R-HSA-5663202 Diseases of signal transduction
R-HSA-1643685 Disease

-  Other Names for This Gene
  Alternate Gene Symbols: B2R6L4, D6W5Y1, NM_002695, NP_002686, O43380, P19388, Q6PIH5, Q9BT06, RPAB1_HUMAN
UCSC ID: uc002lre.4
RefSeq Accession: NM_002695
Protein: P19388 (aka RPAB1_HUMAN)
CCDS: CCDS12056.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_002695.3
exon count: 8CDS single in 3' UTR: no RNA size: 2866
ORF size: 633CDS single in intron: no Alignment % ID: 99.97
txCdsPredict score: 1400.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
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-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.