Human Gene PDPK1 (uc002cqs.4)
  Description: Homo sapiens 3-phosphoinositide dependent protein kinase-1 (PDPK1), transcript variant 1, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr16:2,587,965-2,653,191 Size: 65,227 Total Exon Count: 14 Strand: +
Coding Region
   Position: hg19 chr16:2,588,114-2,647,768 Size: 59,655 Coding Exon Count: 14 

Page IndexSequence and LinksUniProtKB CommentsPrimersGenetic AssociationsMalaCards
CTDGene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein Structure
Other SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther NamesModel Information
Methods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr16:2,587,965-2,653,191)mRNA (may differ from genome)Protein (556 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDLynxMalacards
MGIneXtProtOMIMPubMedReactomeUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: PDPK1_HUMAN
DESCRIPTION: RecName: Full=3-phosphoinositide-dependent protein kinase 1; Short=hPDK1; EC=2.7.11.1;
FUNCTION: Serine/threonine kinase which acts as a master kinase, phosphorylating and activating a subgroup of the AGC family of protein kinases. Its targets include: protein kinase B (PKB/AKT1, PKB/AKT2, PKB/AKT3), p70 ribosomal protein S6 kinase (RPS6KB1), p90 ribosomal protein S6 kinase (RPS6KA1, RPS6KA2 and RPS6KA3), cyclic AMP-dependent protein kinase (PRKACA), protein kinase C (PRKCD and PRKCZ), serum and glucocorticoid-inducible kinase (SGK1, SGK2 and SGK3), p21-activated kinase-1 (PAK1), protein kinase PKN (PKN1 and PKN2). Plays a central role in the transduction of signals from insulin by providing the activating phosphorylation to PKB/AKT1, thus propagating the signal to downstream targets controlling cell proliferation and survival, as well as glucose and amino acid uptake and storage. Negatively regulates the TGF-beta-induced signaling by: modulating the association of SMAD3 and SMAD7 with TGF-beta receptor, phosphorylating SMAD2, SMAD3, SMAD4 and SMAD7, preventing the nuclear translocation of SMAD3 and SMAD4 and the translocation of SMAD7 from the nucleus to the cytoplasm in response to TGF-beta. Activates PPARG transcriptional activity and promotes adipocyte differentiation. Activates the NF-kappa-B pathway via phosphorylation of IKKB. The tyrosine phosphorylated form is crucial for the regulation of focal adhesions by angiotensin II. Controls proliferation, survival, and growth of developing pancreatic cells. Participates in the regulation of Ca(2+) entry and Ca(2+)-activated K(+) channels of mast cells. Essential for the motility of vascular endothelial cells (ECs) and is involved in the regulation of their chemotaxis. Plays a critical role in cardiac homeostasis by serving as a dual effector for cell survival and beta-adrenergic response. Plays an important role during thymocyte development by regulating the expression of key nutrient receptors on the surface of pre-T cells and mediating Notch-induced cell growth and proliferative responses. Provides negative feedback inhibition to toll-like receptor-mediated NF- kappa-B activation in macrophages. Isoform 3 is catalytically inactive.
CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
ENZYME REGULATION: Homodimerization regulates its activity by maintaining the kinase in an autoinhibitory conformation. NPRL2 down-regulates its activity by interfering with tyrosine phosphorylation at the Tyr-9, Tyr-373 and Tyr-376 residues. The 14-3-3 protein YWHAQ acts as a negative regulator by association with the residues surrounding the Ser-241 residue. STRAP positively regulates its activity by enhancing its autophosphorylation and by stimulating its dissociation from YWHAQ. SMAD2, SMAD3, SMAD4 and SMAD7 also positively regulate its activity by stimulating its dissociation from YWHAQ. Activated by phosphorylation on Tyr-9, Tyr-373 and Tyr-376 by INSR in response to insulin.
SUBUNIT: Homodimer in its autoinhibited state. Active as monomer. Interacts with NPRL2, PPARG, PAK1, PTK2B, GRB14, PKN1 (via C- terminus), STRAP and IKKB. The Tyr-9 phosphorylated form interacts with SRC, RASA1 and CRK (via their SH2 domains). Interacts with SGK3 in a phosphorylation-dependent manner. The tyrosine- phosphorylated form interacts with PTPN6. The Ser-241 phosphorylated form interacts with YWHAH and YWHAQ. Binds INSR in response to insulin. Interacts (via PH domain) with SMAD3, SMAD4 and SMAD7. Interacts with PKN2; the interaction stimulates PDPK1 autophosphorylation, its PI(3,4,5)P3-dependent kinase activity toward 'Ser-473' of AKT1 but also activates its kinase activity toward PRKCD and PRKCZ.
INTERACTION: Q00005:PPP2R2B; NbExp=8; IntAct=EBI-717097, EBI-1052159;
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cell membrane; Peripheral membrane protein. Cell junction, focal adhesion. Note=Tyrosine phosphorylation seems to occur only at the cell membrane. Translocates to the cell membrane following insulin stimulation by a mechanism that involves binding to GRB14 and INSR. SRC and HSP90 promote its localization to the cell membrane. Its nuclear localization is dependent on its association with PTPN6 and its phosphorylation at Ser-396. Restricted to the nucleus in neuronal cells while in non-neuronal cells it is found in the cytoplasm. The Ser-241 phosphorylated form is distributed along the perinuclear region in neuronal cells while in non- neuronal cells it is found in both the nucleus and the cytoplasm. IGF1 transiently increases phosphorylation at Ser-241 of neuronal PDPK1, resulting in its translocation to other cellular compartments. The tyrosine-phosphorylated form colocalizes with PTK2B in focal adhesions after angiotensin II stimulation.
TISSUE SPECIFICITY: Appears to be expressed ubiquitously. The Tyr- 9 phosphorylated form is markedly increased in diseased tissue compared with normal tissue from lung, liver, colon and breast.
INDUCTION: Stimulated by insulin, and the oxidants hydrogen peroxide and peroxovanadate.
DOMAIN: The PH domain plays a pivotal role in the localization and nuclear import of PDPK1 and is also essential for its homodimerization.
PTM: Phosphorylation on Ser-241 in the activation loop is required for full activity. PDPK1 itself can autophosphorylate Ser-241, leading to its own activation. Autophosphorylation is inhibited by the apoptotic C-terminus cleavage product of PKN2 (By similarity). Tyr-9 phosphorylation is critical for stabilization of both PDPK1 and the PDPK1/SRC complex via HSP90-mediated protection of PDPK1 degradation. Angiotensin II stimulates the tyrosine phosphorylation of PDPK1 in vascular smooth muscle in a calcium- and SRC-dependent manner. Phosphorylated on Tyr-9, Tyr-373 and Tyr-376 by INSR in response to insulin. Palmitate negatively regulates autophosphorylation at Ser-241 and palmitate-induced phosphorylation at Ser-529 and Ser-501 by PKC/PRKCQ negatively regulates its ability to phosphorylate PKB/AKT1. Phosphorylation at Thr-354 by MELK partially inhibits kinase activity, the inhibition is cooperatively enhanced by phosphorylation at Ser-394 and Ser-398 by MAP3K5.
PTM: Autophosphorylated; autophosphorylation is inhibited by the apoptotic C-terminus cleavage product of PKN2 (By similarity).
PTM: Monoubiquitinated in the kinase domain, deubiquitinated by USP4.
SIMILARITY: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDPK1 subfamily.
SIMILARITY: Contains 1 PH domain.
SIMILARITY: Contains 1 protein kinase domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): PDPK1
CDC HuGE Published Literature: PDPK1

-  MalaCards Disease Associations
  MalaCards Gene Search: PDPK1
Diseases sorted by gene-association score: lung cancer (2), intestinal obstruction (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene
  • C059514 resveratrol
  • D004317 Doxorubicin
  • D008070 Lipopolysaccharides
  • D014108 Tosylphenylalanyl Chloromethyl Ketone
  • C105934 celecoxib
  • C028474 1,4-bis(2-(3,5-dichloropyridyloxy))benzene
  • C016403 2,4-dinitrotoluene
  • C023514 2,6-dinitrotoluene
  • C518576 2-methylbutyric acid 4-((1,3)dioxan-5-ylmethoxyimino)-8-(2-(4-hydroxy-6-oxo-tetrahydropyran-2-yl)ethyl -7-methyl-6-oxo-1,2,3,4,6,7,8,8a-octahydronaphthyl)heptanoate
  • C009505 4,4'-diaminodiphenylmethane
          more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 17.17 RPKM in Brain - Cerebellar Hemisphere
Total median expression: 418.37 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -75.20149-0.505 Picture PostScript Text
3' UTR -2004.465423-0.370 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011009 - Kinase-like_dom
IPR011993 - PH_like_dom
IPR000719 - Prot_kinase_cat_dom
IPR017441 - Protein_kinase_ATP_BS
IPR002290 - Ser/Thr_dual-sp_kinase_dom
IPR008271 - Ser/Thr_kinase_AS

Pfam Domains:
PF00069 - Protein kinase domain
PF07714 - Protein tyrosine kinase
PF14531 - Kinase-like
PF14593 - PH domain

SCOP Domains:
56112 - Protein kinase-like (PK-like)

Protein Data Bank (PDB) 3-D Structure
MuPIT help
1H1W - X-ray MuPIT 1OKY - X-ray MuPIT 1OKZ - X-ray MuPIT 1UU3 - X-ray MuPIT 1UU7 - X-ray MuPIT 1UU8 - X-ray MuPIT 1UU9 - X-ray 1UVR - X-ray MuPIT 1W1D - X-ray MuPIT 1W1G - X-ray MuPIT 1W1H - X-ray MuPIT 1Z5M - X-ray MuPIT 2BIY - X-ray MuPIT 2PE0 - X-ray MuPIT 2PE1 - X-ray MuPIT 2PE2 - X-ray MuPIT 2R7B - X-ray MuPIT 2VKI - X-ray MuPIT 2XCH - X-ray MuPIT 2XCK - X-ray MuPIT 3H9O - X-ray 3HRC - X-ray MuPIT 3HRF - X-ray MuPIT 3ION - X-ray MuPIT 3IOP - X-ray MuPIT 3NAX - X-ray MuPIT 3NAY - X-ray MuPIT 3NUN - X-ray MuPIT 3NUS - X-ray MuPIT 3NUU - X-ray MuPIT 3NUY - X-ray MuPIT 3ORX - X-ray MuPIT 3ORZ - X-ray MuPIT 3OTU - X-ray MuPIT 3PWY - X-ray MuPIT 3QC4 - X-ray MuPIT 3QCQ - X-ray MuPIT 3QCS - X-ray MuPIT 3QCX - X-ray MuPIT 3QCY - X-ray MuPIT 3QD0 - X-ray MuPIT 3QD3 - X-ray MuPIT 3QD4 - X-ray MuPIT 3RCJ - X-ray MuPIT 3RWP - X-ray MuPIT 3RWQ - X-ray MuPIT 3SC1 - X-ray MuPIT 4A06 - X-ray MuPIT 4A07 - X-ray MuPIT 4AW0 - X-ray MuPIT 4AW1 - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on O15530
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserGenome BrowserNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
 Protein SequenceProtein Sequence   
 AlignmentAlignment   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004676 3-phosphoinositide-dependent protein kinase activity
GO:0005158 insulin receptor binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016004 phospholipase activator activity
GO:0016301 kinase activity
GO:0016740 transferase activity
GO:0019901 protein kinase binding
GO:0043274 phospholipase binding

Biological Process:
GO:0002223 stimulatory C-type lectin receptor signaling pathway
GO:0003323 type B pancreatic cell development
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006468 protein phosphorylation
GO:0006469 negative regulation of protein kinase activity
GO:0006972 hyperosmotic response
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0010518 positive regulation of phospholipase activity
GO:0010594 regulation of endothelial cell migration
GO:0010667 negative regulation of cardiac muscle cell apoptotic process
GO:0016310 phosphorylation
GO:0016477 cell migration
GO:0018105 peptidyl-serine phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0019722 calcium-mediated signaling
GO:0030036 actin cytoskeleton organization
GO:0030168 platelet activation
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
GO:0031295 T cell costimulation
GO:0032148 activation of protein kinase B activity
GO:0032869 cellular response to insulin stimulus
GO:0034122 negative regulation of toll-like receptor signaling pathway
GO:0035556 intracellular signal transduction
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043304 regulation of mast cell degranulation
GO:0043524 negative regulation of neuron apoptotic process
GO:0043536 positive regulation of blood vessel endothelial cell migration
GO:0045766 positive regulation of angiogenesis
GO:0046777 protein autophosphorylation
GO:0048041 focal adhesion assembly
GO:0050852 T cell receptor signaling pathway
GO:0051281 positive regulation of release of sequestered calcium ion into cytosol
GO:0071364 cellular response to epidermal growth factor stimulus
GO:0097191 extrinsic apoptotic signaling pathway
GO:1903078 positive regulation of protein localization to plasma membrane
GO:1903672 positive regulation of sprouting angiogenesis
GO:1905564 positive regulation of vascular endothelial cell proliferation
GO:1990416 cellular response to brain-derived neurotrophic factor stimulus
GO:2000352 negative regulation of endothelial cell apoptotic process

Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0014069 postsynaptic density
GO:0016020 membrane
GO:0030054 cell junction
GO:0031410 cytoplasmic vesicle
GO:0042995 cell projection
GO:0043204 perikaryon


-  Descriptions from all associated GenBank mRNAs
  AB209835 - Homo sapiens mRNA for 3-phosphoinositide dependent protein kinase-1 variant protein.
BC006339 - Homo sapiens 3-phosphoinositide dependent protein kinase-1, mRNA (cDNA clone MGC:12726 IMAGE:4079551), complete cds.
BC012103 - Homo sapiens 3-phosphoinositide dependent protein kinase-1, mRNA (cDNA clone MGC:20087 IMAGE:4561371), complete cds.
AK131060 - Homo sapiens cDNA FLJ29026 fis, clone PRS04322, highly similar to 3-phosphoinositide dependent protein kinase-1 (EC 2.7.1.37).
AK222581 - Homo sapiens mRNA for 3-phosphoinositide dependent protein kinase-1 variant, clone: CAS01142.
AF017995 - Homo sapiens 3-phosphoinositide dependent protein kinase-1 (PDK1) mRNA, complete cds.
Y15056 - Homo sapiens mRNA for PkB kinase.
BC033494 - Homo sapiens 3-phosphoinositide dependent protein kinase-1, mRNA (cDNA clone MGC:35290 IMAGE:5176294), complete cds.
AB463382 - Synthetic construct DNA, clone: pF1KB8111, Homo sapiens PDPK1 gene for 3-phosphoinositide dependent protein kinase-1, without stop codon, in Flexi system.
DQ892297 - Synthetic construct clone IMAGE:100004927; FLH184990.01X; RZPDo839E01146D 3-phosphoinositide dependent protein kinase-1 (PDPK1) gene, encodes complete protein.
DQ895496 - Synthetic construct Homo sapiens clone IMAGE:100009956; FLH184986.01L; RZPDo839E01145D 3-phosphoinositide dependent protein kinase-1 (PDPK1) gene, encodes complete protein.
GQ129441 - Synthetic construct Homo sapiens clone HAIB:100068473; DKFZo004C0334 3-phosphoinositide dependent protein kinase-1 protein (PDPK1) gene, partial cds.
EU832784 - Synthetic construct Homo sapiens clone HAIB:100067813; DKFZo008C0333 3-phosphoinositide dependent protein kinase-1 protein (PDPK1) gene, encodes complete protein.
CU689632 - Synthetic construct Homo sapiens gateway clone IMAGE:100019354 5' read PDPK1 mRNA.
KJ891774 - Synthetic construct Homo sapiens clone ccsbBroadEn_01168 PDPK1 gene, encodes complete protein.
KJ905256 - Synthetic construct Homo sapiens clone ccsbBroadEn_14741 PDPK1 gene, encodes complete protein.
CR536517 - Homo sapiens full open reading frame cDNA clone RZPDo834D0722D for gene PDPK1, 3-phosphoinositide dependent protein kinase-1; complete cds, incl. stopcodon.
BC040324 - Homo sapiens 3-phosphoinositide dependent protein kinase-1, mRNA (cDNA clone IMAGE:4830546), with apparent retained intron.
AJ785968 - Homo sapiens mRNA for PDPK2 protein.
AK293900 - Homo sapiens cDNA FLJ59188 complete cds, highly similar to 3-phosphoinositide-dependent protein kinase 1(EC 2.7.11.1).
JD480973 - Sequence 461997 from Patent EP1572962.
JD021934 - Sequence 2958 from Patent EP1572962.
JD036280 - Sequence 17304 from Patent EP1572962.
DQ572503 - Homo sapiens piRNA piR-40615, complete sequence.
JD189421 - Sequence 170445 from Patent EP1572962.
JD459109 - Sequence 440133 from Patent EP1572962.
JD269899 - Sequence 250923 from Patent EP1572962.
DQ589300 - Homo sapiens piRNA piR-56412, complete sequence.
DQ582879 - Homo sapiens piRNA piR-32991, complete sequence.
DQ597273 - Homo sapiens piRNA piR-35339, complete sequence.
DQ580357 - Homo sapiens piRNA piR-48469, complete sequence.
AL157446 - Homo sapiens mRNA; cDNA DKFZp434H119 (from clone DKFZp434H119).
DQ589347 - Homo sapiens piRNA piR-56459, complete sequence.
JD098917 - Sequence 79941 from Patent EP1572962.
JD343481 - Sequence 324505 from Patent EP1572962.
JD482456 - Sequence 463480 from Patent EP1572962.
JD521903 - Sequence 502927 from Patent EP1572962.
JD280573 - Sequence 261597 from Patent EP1572962.
JD310358 - Sequence 291382 from Patent EP1572962.
AK095507 - Homo sapiens cDNA FLJ38188 fis, clone FCBBF1000197.
JD428924 - Sequence 409948 from Patent EP1572962.
JD096604 - Sequence 77628 from Patent EP1572962.
JD184497 - Sequence 165521 from Patent EP1572962.
JD393980 - Sequence 375004 from Patent EP1572962.
JD539116 - Sequence 520140 from Patent EP1572962.
JD515056 - Sequence 496080 from Patent EP1572962.
JD246357 - Sequence 227381 from Patent EP1572962.
JD162186 - Sequence 143210 from Patent EP1572962.
JD058538 - Sequence 39562 from Patent EP1572962.
JD299996 - Sequence 281020 from Patent EP1572962.
JD463353 - Sequence 444377 from Patent EP1572962.
DQ575960 - Homo sapiens piRNA piR-44072, complete sequence.
DQ571996 - Homo sapiens piRNA piR-40108, complete sequence.
JD492248 - Sequence 473272 from Patent EP1572962.
JD292274 - Sequence 273298 from Patent EP1572962.
JD090045 - Sequence 71069 from Patent EP1572962.
JD103773 - Sequence 84797 from Patent EP1572962.
JD056498 - Sequence 37522 from Patent EP1572962.
DQ600114 - Homo sapiens piRNA piR-38180, complete sequence.
JD287676 - Sequence 268700 from Patent EP1572962.
BC012540 - Homo sapiens 3-phosphoinositide dependent protein kinase-1, mRNA (cDNA clone IMAGE:4278655).
JD488674 - Sequence 469698 from Patent EP1572962.
JD245397 - Sequence 226421 from Patent EP1572962.
JD088224 - Sequence 69248 from Patent EP1572962.
JD088225 - Sequence 69249 from Patent EP1572962.
JD368436 - Sequence 349460 from Patent EP1572962.
JD368437 - Sequence 349461 from Patent EP1572962.
DQ601053 - Homo sapiens piRNA piR-39119, complete sequence.
JD479816 - Sequence 460840 from Patent EP1572962.
JD355752 - Sequence 336776 from Patent EP1572962.
JD378794 - Sequence 359818 from Patent EP1572962.
JD219524 - Sequence 200548 from Patent EP1572962.
JD426840 - Sequence 407864 from Patent EP1572962.
JD375023 - Sequence 356047 from Patent EP1572962.
JD563404 - Sequence 544428 from Patent EP1572962.
JD500470 - Sequence 481494 from Patent EP1572962.
BC000789 - Homo sapiens 3-phosphoinositide dependent protein kinase-1, mRNA (cDNA clone IMAGE:3451347).
JD223489 - Sequence 204513 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa03320 - PPAR signaling pathway
hsa04150 - mTOR signaling pathway
hsa04510 - Focal adhesion
hsa04910 - Insulin signaling pathway
hsa04960 - Aldosterone-regulated sodium reabsorption
hsa05213 - Endometrial cancer
hsa05215 - Prostate cancer
hsa05223 - Non-small cell lung cancer

BioCarta from NCI Cancer Genome Anatomy Project
h_eif4Pathway - Regulation of eIF4e and p70 S6 Kinase
h_mTORPathway - mTOR Signaling Pathway
h_ptdinsPathway - Phosphoinositides and their downstream targets.
h_igf1mtorpathway - Skeletal muscle hypertrophy is regulated via AKT/mTOR pathway
h_gsk3Pathway - Inactivation of Gsk3 by AKT causes accumulation of b-catenin in Alveolar Macrophages
h_ptenPathway - PTEN dependent cell cycle arrest and apoptosis
h_aktPathway - AKT Signaling Pathway

Reactome (by CSHL, EBI, and GO)

Protein O15530 (Reactome details) participates in the following event(s):

R-HSA-109701 PDPK1 binds PIP3
R-HSA-198284 PIP3 recruits PDK1 and AKT to the membrane
R-HSA-202164 Translocation of PDK1 to Plasma membrane
R-HSA-2219524 PDPK1 binds PIP2
R-HSA-2316429 PIP3 recruits PDPK1 to the membrane
R-HSA-202394 Translocation of CARMA1 to Plasma membrane
R-HSA-437192 PDK1 binds PKC zeta
R-HSA-2317314 AKT binds PDPK1
R-HSA-5623632 RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3
R-HSA-198270 PDPK1 phosphorylates AKT at T308
R-HSA-5623667 PDPK1 phosphorylates PKN1,2,3
R-HSA-2243937 PIP2-bound p-S473-AKT1 mutant binds PIP2-bound PDPK1
R-HSA-2243942 PDPK1 phosphorylates AKT1 E17K mutant
R-HSA-5218821 PDK1 phosphorylates PKC
R-HSA-442739 Phosphorylation by PDK1
R-HSA-109702 PDPK1 phosphorylates AKT2
R-HSA-6795473 PDPK1 phosphorylates SGK1
R-HSA-202437 Phosphorylation of CARMA1
R-HSA-202443 Oligomerization of CARMA1
R-HSA-202466 Interaction of Bcl10 to CARMA1
R-HSA-202222 Phosphorylation of PKC theta
R-HSA-437195 PDK1 activates PKC zeta
R-HSA-432110 Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding
R-HSA-202459 Phosphorylation of Bcl10
R-HSA-202478 Interaction and oligomerization of MALT1 to Bcl10
R-HSA-202489 Oligomerization of Bcl10
R-HSA-202472 Translocation of TRAF6 to CBM complex
R-HSA-202510 Activation of TAK1-TAB2 complex
R-HSA-202453 Auto-ubiquitination of TRAF6
R-HSA-202500 Activation of IKK complex
R-HSA-165158 Activation of AKT2
R-HSA-392451 G beta:gamma signalling through PI3Kgamma
R-HSA-202424 Downstream TCR signaling
R-HSA-2730905 Role of LAT2/NTAL/LAB on calcium mobilization
R-HSA-1257604 PIP3 activates AKT signaling
R-HSA-114604 GPVI-mediated activation cascade
R-HSA-389357 CD28 dependent PI3K/Akt signaling
R-HSA-5218920 VEGFR2 mediated vascular permeability
R-HSA-5625740 RHO GTPases activate PKNs
R-HSA-5674400 Constitutive Signaling by AKT1 E17K in Cancer
R-HSA-109704 PI3K Cascade
R-HSA-5218921 VEGFR2 mediated cell proliferation
R-HSA-397795 G-protein beta:gamma signalling
R-HSA-202403 TCR signaling
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling
R-HSA-9006925 Intracellular signaling by second messengers
R-HSA-76002 Platelet activation, signaling and aggregation
R-HSA-389356 CD28 co-stimulation
R-HSA-4420097 VEGFA-VEGFR2 Pathway
R-HSA-444257 RSK activation
R-HSA-6804757 Regulation of TP53 Degradation
R-HSA-195258 RHO GTPase Effectors
R-HSA-2219528 PI3K/AKT Signaling in Cancer
R-HSA-354192 Integrin alphaIIb beta3 signaling
R-HSA-112399 IRS-mediated signalling
R-HSA-388396 GPCR downstream signalling
R-HSA-1280218 Adaptive Immune System
R-HSA-168249 Innate Immune System
R-HSA-162582 Signal Transduction
R-HSA-109582 Hemostasis
R-HSA-388841 Costimulation by the CD28 family
R-HSA-194138 Signaling by VEGF
R-HSA-442742 CREB phosphorylation through the activation of Ras
R-HSA-6806003 Regulation of TP53 Expression and Degradation
R-HSA-194315 Signaling by Rho GTPases
R-HSA-5663202 Diseases of signal transduction
R-HSA-76009 Platelet Aggregation (Plug Formation)
R-HSA-9006921 Integrin signaling
R-HSA-74751 Insulin receptor signalling cascade
R-HSA-2428928 IRS-related events triggered by IGF1R
R-HSA-372790 Signaling by GPCR
R-HSA-168256 Immune System
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
R-HSA-438064 Post NMDA receptor activation events
R-HSA-5633007 Regulation of TP53 Activity
R-HSA-1643685 Disease
R-HSA-74752 Signaling by Insulin receptor
R-HSA-2428924 IGF1R signaling cascade
R-HSA-442755 Activation of NMDA receptor and postsynaptic events
R-HSA-3700989 Transcriptional Regulation by TP53
R-HSA-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission
R-HSA-212436 Generic Transcription Pathway
R-HSA-2871837 FCERI mediated NF-kB activation
R-HSA-5607764 CLEC7A (Dectin-1) signaling
R-HSA-112315 Transmission across Chemical Synapses
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-5621481 C-type lectin receptors (CLRs)
R-HSA-112316 Neuronal System
R-HSA-74160 Gene expression (Transcription)

-  Other Names for This Gene
  Alternate Gene Symbols: NM_002613, NP_002604, O15530, PDK1, PDPK1_HUMAN, Q6FI20, Q8IV52, Q9BRD5, uc002cqs.3
UCSC ID: uc002cqs.4
RefSeq Accession: NM_002613
Protein: O15530 (aka PDPK1_HUMAN or PDPK_HUMAN)
CCDS: CCDS10472.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_002613.4
exon count: 14CDS single in 3' UTR: no RNA size: 7243
ORF size: 1671CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2967.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
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-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.