Description: Homo sapiens poly (ADP-ribose) polymerase family, member 14 (PARP14), mRNA. RefSeq Summary (NM_017554): This gene encodes a member of the poly(ADP-ribose) polymerase (PARP) protein family. The encoded anti-apoptotic protein may regulate aerobic glycolysis and promote survival of cancer cells. Increased expression of this gene has been reported in a variety of tumor types. [provided by RefSeq, Jul 2016]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Transcript (Including UTRs) Position: hg19 chr3:122,399,672-122,449,687 Size: 50,016 Total Exon Count: 17 Strand: + Coding Region Position: hg19 chr3:122,399,731-122,447,444 Size: 47,714 Coding Exon Count: 17
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Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): PARP14 CDC HuGE Published Literature: PARP14 Positive Disease Associations: Hip Related Studies:
Hip Douglas P Kiel et al. BMC medical genetics 2007, Genome-wide association with bone mass and geometry in the Framingham Heart Study., BMC medical genetics.
[PubMed 17903296]
The FHS 100K SNP project offers an unbiased genome-wide strategy to identify new candidate loci and to replicate previously suggested candidate genes for osteoporosis.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q460N5
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0002376 immune system process GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006471 protein ADP-ribosylation GO:0010629 negative regulation of gene expression GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein GO:0042532 negative regulation of tyrosine phosphorylation of STAT protein GO:0045087 innate immune response GO:0060336 negative regulation of interferon-gamma-mediated signaling pathway GO:0070212 protein poly-ADP-ribosylation GO:1902216 positive regulation of interleukin-4-mediated signaling pathway
US Server
