Description: Homo sapiens neuropeptide Y (NPY), mRNA. RefSeq Summary (NM_000905): This gene encodes a neuropeptide that is widely expressed in the central nervous system and influences many physiological processes, including cortical excitability, stress response, food intake, circadian rhythms, and cardiovascular function. The neuropeptide functions through G protein-coupled receptors to inhibit adenylyl cyclase, activate mitogen-activated protein kinase (MAPK), regulate intracellular calcium levels, and activate potassium channels. A polymorphism in this gene resulting in a change of leucine 7 to proline in the signal peptide is associated with elevated cholesterol levels, higher alcohol consumption, and may be a risk factor for various metabolic and cardiovascular diseases. The protein also exhibits antimicrobial activity against bacteria and fungi. [provided by RefSeq, Oct 2014]. Transcript (Including UTRs) Position: hg19 chr7:24,323,807-24,331,484 Size: 7,678 Total Exon Count: 4 Strand: + Coding Region Position: hg19 chr7:24,324,860-24,331,306 Size: 6,447 Coding Exon Count: 3
ID:NPY_HUMAN DESCRIPTION: RecName: Full=Pro-neuropeptide Y; Contains: RecName: Full=Neuropeptide Y; AltName: Full=Neuropeptide tyrosine; Short=NPY; Contains: RecName: Full=C-flanking peptide of NPY; Short=CPON; Flags: Precursor; FUNCTION: NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone. SUBCELLULAR LOCATION: Secreted. TISSUE SPECIFICITY: One of the most abundant peptides in the nervous system. Also found in some chromaffin cells of the adrenal medulla. SIMILARITY: Belongs to the NPY family. WEB RESOURCE: Name=Wikipedia; Note=Neuropeptide Y entry; URL="http://en.wikipedia.org/wiki/Neuropeptide_Y";
alcohol abuse Mottagui-Tabar, S. et al. 2005, A novel single nucleotide polymorphism of the neuropeptide Y (NPY) gene associated with alcohol dependence., Alcoholism, clinical and experimental research. 2005 May;29(5):702-7.
[PubMed 15897713]
We report a novel polymorphism at position -602 in the 5' region of the NPY gene that is significantly associated with alcohol dependence. We also describe the haplotype frequencies and linkage dysequilibrium pattern of four variations in that region.
alcohol dependence Lappalainen, J. et al. 2002, A functional neuropeptide Y Leu7Pro polymorphism associated with alcohol dependence in a large population sample from the United States., Archives of general psychiatry. 2002 Sep;59(9):825-31.
[PubMed 12215082]
These results suggest that the NPY Pro7 allele is a risk factor for alcohol dependence. This is only the second specific genetic mechanism ever identified that modulates risk for alcohol dependence.
alcohol dependence Lappalainen J et al. 2002, A functional neuropeptide Y Leu7Pro polymorphism associated with alcohol dependence in a large population sample from the United States., Archives of general psychiatry. 2002 Sep;59(9):825-31.
[PubMed 12215082]
These results suggest that the NPY Pro7 allele is a risk factor for alcohol dependence. This is only the second specific genetic mechanism ever identified that modulates risk for alcohol dependence.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P01303
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
