ID:KHDR3_HUMAN DESCRIPTION: RecName: Full=KH domain-containing, RNA-binding, signal transduction-associated protein 3; AltName: Full=RNA-binding protein T-Star; AltName: Full=Sam68-like mammalian protein 2; Short=SLM-2; AltName: Full=Sam68-like phosphotyrosine protein; FUNCTION: RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. May play a role as a negative regulator of cell growth. Inhibits cell proliferation. Involved in splice site selection of vascular endothelial growth factor. Induces an increased concentration-dependent incorporation of exon in CD44 pre-mRNA by direct binding to purine-rich exonic enhancer. RNA- binding abilities are down-regulated by tyrosine kinase PTK6. Involved in post-transcriptional regulation of HIV-1 gene expression. Binds preferentially to the 5'-[AU]UAAA-3' motif in vitro. SUBUNIT: Self-associates to form homooligomers. Interacts with the splicing regulatory proteins SFRS9, SAFB and YTHDC1. Interacts also with HNRPL and SLM1/KHDRBS2 (By similarity). Interacts with KHDRBS1, RBMX, RBMY1A1 and with p85 subunit of PI3-kinase. Interacts also with SIAH1 which promotes targeting for degradation. INTERACTION: Q8WX92:COBRA1; NbExp=2; IntAct=EBI-722504, EBI-347721; SUBCELLULAR LOCATION: Nucleus. Note=Localized in a compartment adjacent to the nucleolus, but distinct from the peri-nucleolar one. TISSUE SPECIFICITY: Ubiquitous with higher expression in testis, skeletal muscle and brain. Expressed in the kidney only in podocytes, the glomerular epithelial cells of the kidney. Strongly expressed after meiosis. INDUCTION: Induced in proteinuric diseases. Down-regulated in immortalized fibroblasts isolated after a proliferative crisis accompanied with massive cell death. DOMAIN: The proline-rich site binds the SH3 domain of the p85 subunit of PI3-kinase. PTM: Phosphorylated on tyrosine residues. Isoform 1 C-terminal region is tyrosine-rich, but isoform 2 lacking this C-terminal region is also tyrosine-phosphorylated. SIMILARITY: Belongs to the KHDRBS family. SIMILARITY: Contains 1 KH domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
SCOP Domains: 54791 - Eukaryotic type KH-domain (KH-domain type I)
ModBase Predicted Comparative 3D Structure on O75525
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
