Description: Homo sapiens insulin receptor substrate 4 (IRS4), mRNA. RefSeq Summary (NM_003604): IRS4 encodes the insulin receptor substrate 4, a cytoplasmic protein that contains many potential tyrosine and serine/threonine phosphorylation sites. Tyrosine-phosphorylated IRS4 protein has been shown to associate with cytoplasmic signalling molecules that contain SH2 domains. The IRS4 protein is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation.. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chrX:107,975,727-107,979,607 Size: 3,881 Total Exon Count: 1 Strand: - Coding Region Position: hg19 chrX:107,975,801-107,979,574 Size: 3,774 Coding Exon Count: 1
ID:IRS4_HUMAN DESCRIPTION: RecName: Full=Insulin receptor substrate 4; Short=IRS-4; AltName: Full=160 kDa phosphotyrosine protein; Short=py160; AltName: Full=Phosphoprotein of 160 kDa; Short=pp160; FUNCTION: Acts as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such as insulin receptor, IGF1R and FGFR1, and a complex network of intracellular signaling molecules containing SH2 domains. Involved in the IGF1R mitogenic signaling pathway. Promotes the AKT1 signaling pathway and BAD phosphorylation during insulin stimulation without activation of RPS6KB1 or the inhibition of apoptosis. Interaction with GRB2 enhances insulin-stimulated mitogen-activated protein kinase activity. May be involved in nonreceptor tyrosine kinase signaling in myoblasts. Plays a pivotal role in the proliferation/differentiation of hepatoblastoma cell through EPHB2 activation upon IGF1 stimulation. May play a role in the signal transduction in response to insulin and to a lesser extent in response to IL4 and GH on mitogenesis. Plays a role in growth, reproduction and glucose homeostasis. May act as negative regulators of the IGFI signaling pathway by suppressing the function of IRS1 and IRS2. SUBUNIT: Interacts with SOCS6 in response to stimulatiom with either insulin or IGF1 (By similarity). Interacts with CRK and CRKL. Interaction with CRK is stronger than with CRKL. Interacts with CRK via the phosphorylated YXXM motifs. Interacts with GRB2 and PIK3R1. Interacts with PLC-gamma, SHC1, PTK6, PPP4C and NISCH. SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein; Cytoplasmic side. TISSUE SPECIFICITY: Expressed in myoblasts. Expressed in liver and hepatocellular carcinoma. INDUCTION: Down-regulated by PPP4C in a phosphatase activity- dependent manner. PTM: Phosphorylated on tyrosine residues in response to both insulin and IGF1 signaling. Phosphorylated on Tyr-921 in response to FGF2 signaling. Phosphorylation of Tyr-921 is required for GRB2, phospholipase C-gamma and phosphatidylinositol 3-kinase interaction. SIMILARITY: Contains 1 IRS-type PTB domain. SIMILARITY: Contains 1 PH domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O14654
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0007165 signal transduction GO:0008286 insulin receptor signaling pathway GO:0009967 positive regulation of signal transduction GO:0019216 regulation of lipid metabolic process
US Server
