ID:TF3C2_HUMAN DESCRIPTION: RecName: Full=General transcription factor 3C polypeptide 2; AltName: Full=TF3C-beta; AltName: Full=Transcription factor IIIC 110 kDa subunit; Short=TFIIIC 110 kDa subunit; Short=TFIIIC110; AltName: Full=Transcription factor IIIC subunit beta; FUNCTION: Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. May play a direct role in stabilizing interactions of TFIIIC2 with TFIIIC1. SUBUNIT: Part of the TFIIIC subcomplex TFIIIC2, consisting of six subunits, GTF3C1, GTF3C2, GTF3C3, GTF3C4, GTF3C5 and GTF3C6. SUBCELLULAR LOCATION: Nucleus. SIMILARITY: Contains 4 WD repeats.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8WUA4
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006351 transcription, DNA-templated GO:0006383 transcription from RNA polymerase III promoter GO:0042791 5S class rRNA transcription from RNA polymerase III type 1 promoter GO:0042797 tRNA transcription from RNA polymerase III promoter
AF054988 - Homo sapiens clone 23858 unknown mRNA, partial cds. BC020981 - Homo sapiens general transcription factor IIIC, polypeptide 2, beta 110kDa, mRNA (cDNA clone MGC:9704 IMAGE:3849379), complete cds. D13636 - Homo sapiens KIAA0011 mRNA, complete cds. JD503589 - Sequence 484613 from Patent EP1572962. JD250078 - Sequence 231102 from Patent EP1572962. JD357911 - Sequence 338935 from Patent EP1572962. JD240285 - Sequence 221309 from Patent EP1572962. JD495757 - Sequence 476781 from Patent EP1572962. JD504010 - Sequence 485034 from Patent EP1572962. JD195430 - Sequence 176454 from Patent EP1572962. BX647092 - Homo sapiens mRNA; cDNA DKFZp686K15171 (from clone DKFZp686K15171). JD465218 - Sequence 446242 from Patent EP1572962. JD154453 - Sequence 135477 from Patent EP1572962. AK307656 - Homo sapiens cDNA, FLJ97604. JD552131 - Sequence 533155 from Patent EP1572962. JD166480 - Sequence 147504 from Patent EP1572962. JD393043 - Sequence 374067 from Patent EP1572962. JD039237 - Sequence 20261 from Patent EP1572962. BT009799 - Homo sapiens general transcription factor IIIC, polypeptide 2, beta 110kDa mRNA, complete cds. AB463053 - Synthetic construct DNA, clone: pF1KA0011, Homo sapiens GTF3C2 gene for general transcription factor IIIC, polypeptide 2, beta 110kDa, without stop codon, in Flexi system. BC000212 - Homo sapiens general transcription factor IIIC, polypeptide 2, beta 110kDa, mRNA (cDNA clone MGC:1731 IMAGE:3508353), complete cds. KJ901473 - Synthetic construct Homo sapiens clone ccsbBroadEn_10867 GTF3C2 gene, encodes complete protein. CU674088 - Synthetic construct Homo sapiens gateway clone IMAGE:100017719 5' read GTF3C2 mRNA.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q8WUA4 (Reactome details) participates in the following event(s):
R-HSA-76054 Binding of TFIIIC to TFIIIA:Type I Promoter complex R-HSA-83788 Binding of TFIIIC to Type 2 promoter R-HSA-83723 Binding of TFIIIB to TFIIIC:TFIIIA:Type I Promoter complex R-HSA-83790 Binding of TFIIIB to TFIIC: Type 2 Promoter Complex R-HSA-112055 RNA Polymerase III Abortive Initiation At Type 1 Open Promoters R-HSA-112153 RNA Polymerase III Simple Start Sequence Initiation At Type 1 Promoters R-HSA-76060 RNA Polymerase III Promoter Opening at Type 1 Promoters R-HSA-112149 RNA Polymerase III Abortive Initiation At Type 2 Open Promoters R-HSA-112155 RNA Polymerase III Simple Start Sequence Initiation At Type 2 Promoters R-HSA-112150 RNA Polymerase III Promoter Opening at Type 2 Promoters R-HSA-76056 Recruitment of RNA polymerase III to TFIIIB:TFIIIC:TFIIIA:Type 1 Promoter Complex R-HSA-83805 Recruitment of RNA Polymerase III to the TFIIIB:TFIIIC: Type 2 Promoter Complex R-HSA-76061 RNA Polymerase III Transcription Initiation From Type 1 Promoter R-HSA-76066 RNA Polymerase III Transcription Initiation From Type 2 Promoter R-HSA-749476 RNA Polymerase III Abortive And Retractive Initiation R-HSA-76046 RNA Polymerase III Transcription Initiation R-HSA-74158 RNA Polymerase III Transcription R-HSA-74160 Gene expression (Transcription)
US Server
