Description: Homo sapiens FK506 binding protein 5 (FKBP5), transcript variant 1, mRNA. RefSeq Summary (NM_004117): The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It is thought to mediate calcineurin inhibition. It also interacts functionally with mature hetero-oligomeric progesterone receptor complexes along with the 90 kDa heat shock protein and P23 protein. This gene has been found to have multiple polyadenylation sites. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009]. Transcript (Including UTRs) Position: hg19 chr6:35,541,362-35,656,719 Size: 115,358 Total Exon Count: 11 Strand: - Coding Region Position: hg19 chr6:35,543,612-35,610,601 Size: 66,990 Coding Exon Count: 10
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Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): FKBP5 CDC HuGE Published Literature: FKBP5 Positive Disease Associations: depression Related Studies:
depression Binder, E. B. et al. 2004, Polymorphisms in FKBP5 are associated with increased recurrence of depressive episodes and rapid response to antidepressant treatment, Nature genetics. 2004 Dec;36(12):1319-25.
[PubMed 15565110]
These findings support a central role of genes regulating the HPA axis in the causality of depression and the mechanism of action of antidepressant drugs.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q13451
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.