Description: Homo sapiens eukaryotic translation initiation factor 4E (EIF4E), transcript variant 3, mRNA. RefSeq Summary (NM_001130678): The protein encoded by this gene is a component of the eukaryotic translation initiation factor 4F complex, which recognizes the 7-methylguanosine cap structure at the 5' end of messenger RNAs. The encoded protein aids in translation initiation by recruiting ribosomes to the 5'-cap structure. Association of this protein with the 4F complex is the rate-limiting step in translation initiation. This gene acts as a proto-oncogene, and its expression and activation is associated with transformation and tumorigenesis. Several pseudogenes of this gene are found on other chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]. Transcript (Including UTRs) Position: hg19 chr4:99,799,607-99,850,243 Size: 50,637 Total Exon Count: 7 Strand: - Coding Region Position: hg19 chr4:99,802,179-99,850,123 Size: 47,945 Coding Exon Count: 7
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
Pfam Domains: PF01652 - Eukaryotic initiation factor 4E
ModBase Predicted Comparative 3D Structure on P06730-3
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa04150 - mTOR signaling pathway hsa04910 - Insulin signaling pathway
BioCarta from NCI Cancer Genome Anatomy Project h_eifPathway - Eukaryotic protein translation h_eif4Pathway - Regulation of eIF4e and p70 S6 Kinase h_iresPathway - Internal Ribosome entry pathway h_igf1mtorpathway - Skeletal muscle hypertrophy is regulated via AKT/mTOR pathway h_mTORPathway - mTOR Signaling Pathway h_SARSpathway - SARS Coronavirus Protease
Reactome (by CSHL, EBI, and GO)
Protein P06730 (Reactome details) participates in the following event(s):
R-HSA-72631 Formation of the cap-binding eIF4F complex R-HSA-158447 Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC R-HSA-158484 Release of the SLBP independent Histone mRNA from the NPC R-HSA-159050 Release of the Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex R-HSA-72619 eIF2:GTP is hydrolyzed, eIFs are released R-HSA-72622 Release of eIF4E from the inactive eIF4E:4E-BP complex R-HSA-165708 Dissociation of phosphorylated 4EBP1 from eIF4E R-HSA-429955 CCR4-NOT complex deadenylates mRNA R-HSA-429992 PARN deadenylates mRNA R-HSA-165692 Phosphorylation of 4E-BP1 by activated mTORC1 R-HSA-72635 eIF4F binds to mRNP R-HSA-430021 PAN2-PAN3 complex partially deadenylates mRNA R-HSA-8941312 ZCCHC6, ZCCHC11 are mRNA uridyltransferases R-HSA-72621 Ribosomal scanning R-HSA-157849 Formation of translation initiation complexes containing mRNA that does not circularize R-HSA-72697 Start codon recognition R-HSA-156823 Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA R-HSA-156808 Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a 'closed-loop' conformation R-HSA-1678842 Competitive inhibition of translation initiation by ISGylated 4EHP R-HSA-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-159227 Transport of the SLBP independent Mature mRNA R-HSA-159230 Transport of the SLBP Dependant Mature mRNA R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-166208 mTORC1-mediated signalling R-HSA-429947 Deadenylation of mRNA R-HSA-72737 Cap-dependent Translation Initiation R-HSA-159234 Transport of Mature mRNAs Derived from Intronless Transcripts R-HSA-165159 mTOR signalling R-HSA-429914 Deadenylation-dependent mRNA decay R-HSA-72702 Ribosomal scanning and start codon recognition R-HSA-72649 Translation initiation complex formation R-HSA-156827 L13a-mediated translation R-HSA-1169408 ISG15 antiviral mechanism R-HSA-72613 Eukaryotic Translation Initiation R-HSA-72202 Transport of Mature Transcript to Cytoplasm R-HSA-162582 Signal Transduction R-HSA-8953854 Metabolism of RNA R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes R-HSA-72766 Translation R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA R-HSA-913531 Interferon Signaling R-HSA-392499 Metabolism of proteins R-HSA-1280215 Cytokine Signaling in Immune system R-HSA-168256 Immune System
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