Human Gene CREB1 (uc002vcc.3)
  Description: Homo sapiens cAMP responsive element binding protein 1 (CREB1), transcript variant B, mRNA.
RefSeq Summary (NM_134442): This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Alternate splicing of this gene results in several transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016].
Transcript (Including UTRs)
   Position: hg19 chr2:208,394,616-208,470,284 Size: 75,669 Total Exon Count: 9 Strand: +
Coding Region
   Position: hg19 chr2:208,420,360-208,461,782 Size: 41,423 Coding Exon Count: 8 

Page IndexSequence and LinksUniProtKB CommentsPrimersGenetic AssociationsMalaCards
CTDGene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein Structure
Other SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther NamesModel Information
Methods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:208,394,616-208,470,284)mRNA (may differ from genome)Protein (341 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
H-INVHGNCHPRDHuman Cortex Gene ExpressionLynxMalacards
MGIneXtProtOMIMPubMedReactomeUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: CREB1_HUMAN
DESCRIPTION: RecName: Full=Cyclic AMP-responsive element-binding protein 1; Short=CREB-1; Short=cAMP-responsive element-binding protein 1;
FUNCTION: Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells.
SUBUNIT: Interacts with PPRC1. Binds DNA as a dimer. This dimer is stabilized by magnesium ions. Interacts, through the bZIP domain, with the coactivators TORC1/CRTC1, TORC2/CRTC2 and TORC3/CRTC3. When phosphorylated on Ser-133, binds CREBBP (By similarity). Interacts with CREBL2; regulates CREB1 phosphorylation, stability and transcriptional activity (By similarity). Interacts (phosphorylated form) with TOX3. Interacts with ARRB1. Binds to HIPK2. Interacts with SGK1.
INTERACTION: O00470:MEIS1; NbExp=9; IntAct=EBI-711855, EBI-1210694; Q6SA08:TSSK4; NbExp=5; IntAct=EBI-711855, EBI-1202583;
SUBCELLULAR LOCATION: Nucleus.
PTM: Stimulated by phosphorylation. Phosphorylation of both Ser- 133 and Ser-142 in the SCN regulates the activity of CREB and participates in circadian rhythm generation. Phosphorylation of Ser-133 allows CREBBP binding (By similarity). CREBL2 positively regulates phosphorylation at Ser-133 thereby stimulating CREB1 transcriptional activity (By similarity). Phosphorylated upon DNA damage, probably by ATM or ATR. Phosphorylated upon calcium influx by CaMK4 and CaMK2 on Ser-133. CaMK4 is much more potent than CaMK2 in activating CREB. Phosphorylated by CaMK2 on Ser-142. Phosphorylation of Ser-142 blocks CREB-mediated transcription even when Ser-133 is phosphorylated. Phosphorylated by CaMK1 (By similarity). Phosphorylation of Ser-271 by HIPK2 in response to genotoxic stress promotes CREB1 activity, facilitating the recruitment of the coactivator CBP. Phosphorylated at Ser-133 by RPS6KA3, RPS6KA4 and RPS6KA5 in response to mitogenic or stress stimuli.
PTM: Sumoylated with SUMO1. Sumoylation on Lys-304, but not on Lys-285, is required for nuclear localization of this protein. Sumoylation is enhanced under hypoxia, promoting nuclear localization and stabilization.
DISEASE: Defects in CREB1 may be a cause of angiomatoid fibrous histiocytoma (AFH) [MIM:612160]. A distinct variant of malignant fibrous histiocytoma that typically occurs in children and adolescents and is manifest by nodular subcutaneous growth. Characteristic microscopic features include lobulated sheets of histiocyte-like cells intimately associated with areas of hemorrhage and cystic pseudovascular spaces, as well as a striking cuffing of inflammatory cells, mimicking a lymph node metastasis. Note=A chromosomal aberration involving CREB1 is found in a patient with angiomatoid fibrous histiocytoma. Translocation t(2;22)(q33;q12) with CREB1 generates a EWSR1/CREB1 fusion gene that is most common genetic abnormality in this tumor type.
DISEASE: Note=A CREB1 mutation has been found in a patient with multiple congenital anomalies consisting of agenesis of the corpus callosum, cerebellar hypoplasia, severe neonatal respiratory distress refractory to surfactant, thymus hypoplasia, and thyroid follicular hypoplasia (PubMed:22267179).
SIMILARITY: Belongs to the bZIP family.
SIMILARITY: Contains 1 bZIP (basic-leucine zipper) domain.
SIMILARITY: Contains 1 KID (kinase-inducible) domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): CREB1
CDC HuGE Published Literature: CREB1
Positive Disease Associations: suicide
Related Studies:
  1. suicide
    Perlis, R. H. et al. 2007, Association Between Treatment-Emergent Suicidal Ideation With Citalopram and Polymorphisms Near Cyclic Adenosine Monophosphate Response Element Binding Protein in the STAR*D Study, Arch Gen Psychiatry 2007 64(6) 689-97. [PubMed 17548750]
    Polymorphisms that span CREB1 were associated with treatment-emergent suicidality among men with depression, extending an observation of association with male anger expression in a prior independent cohort. If replicated, this finding would suggest that pharmacogenetic testing could facilitate the identification of the small subset of individuals at greater risk during short-term antidepressant treatment.

-  MalaCards Disease Associations
  MalaCards Gene Search: CREB1
Diseases sorted by gene-association score: histiocytoma, angiomatoid fibrous, somatic* (500), melanoma of soft tissue* (247), diabetic encephalopathy (21), fibrous histiocytoma (18), drug addiction (16), coffin-lowry syndrome (16), histiocytoma (15), opiate dependence (13), charcot-marie-tooth disease, type 4c (13), clear cell sarcoma (12), human t-cell leukemia virus type 1 (11), rett syndrome (10), huntington disease (10), t-cell leukemia (9), mood disorder (9), chromosome 16p13.3 deletion syndrome, proximal (8), human t-cell leukemia virus type 2 (6), bipolar disorder (5), hypoxia (5), acrodysostosis (5), amnestic disorder (5), lung sarcoma (5), arrhythmogenic right ventricular dysplasia 1 (4), dyschromatosis universalis hereditaria (4), cerebral hypoxia (4), spinocerebellar ataxia 12 (4), pheochromocytoma (2), prostate cancer (2)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 8.15 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 215.14 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -113.31251-0.451 Picture PostScript Text
3' UTR -2210.318502-0.260 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR004827 - bZIP
IPR003102 - Coactivator_CBP_pKID
IPR001630 - Leuzip_CREB

Pfam Domains:
PF00170 - bZIP transcription factor
PF02173 - pKID domain
PF07716 - Basic region leucine zipper

ModBase Predicted Comparative 3D Structure on P16220
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
 Protein Sequence    
 Alignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0001102 RNA polymerase II activating transcription factor binding
GO:0001190 transcriptional activator activity, RNA polymerase II transcription factor binding
GO:0001225 RNA polymerase II transcription coactivator binding
GO:0003677 DNA binding
GO:0003690 double-stranded DNA binding
GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
GO:0003712 transcription cofactor activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0019899 enzyme binding
GO:0030544 Hsp70 protein binding
GO:0035035 histone acetyltransferase binding
GO:0035497 cAMP response element binding
GO:0042802 identical protein binding
GO:0043565 sequence-specific DNA binding
GO:0044212 transcription regulatory region DNA binding
GO:1990763 arrestin family protein binding

Biological Process:
GO:0001666 response to hypoxia
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0006468 protein phosphorylation
GO:0007165 signal transduction
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007409 axonogenesis
GO:0007568 aging
GO:0007595 lactation
GO:0007613 memory
GO:0007623 circadian rhythm
GO:0008361 regulation of cell size
GO:0008542 visual learning
GO:0010033 response to organic substance
GO:0010629 negative regulation of gene expression
GO:0010944 negative regulation of transcription by competitive promoter binding
GO:0014823 response to activity
GO:0016032 viral process
GO:0021983 pituitary gland development
GO:0030154 cell differentiation
GO:0030879 mammary gland development
GO:0032916 positive regulation of transforming growth factor beta3 production
GO:0033363 secretory granule organization
GO:0033762 response to glucagon
GO:0034670 chemotaxis to arachidonic acid
GO:0035094 response to nicotine
GO:0035729 cellular response to hepatocyte growth factor stimulus
GO:0036120 cellular response to platelet-derived growth factor stimulus
GO:0040018 positive regulation of multicellular organism growth
GO:0042493 response to drug
GO:0042752 regulation of circadian rhythm
GO:0042981 regulation of apoptotic process
GO:0043065 positive regulation of apoptotic process
GO:0045600 positive regulation of fat cell differentiation
GO:0045672 positive regulation of osteoclast differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045899 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046887 positive regulation of hormone secretion
GO:0046889 positive regulation of lipid biosynthetic process
GO:0048145 regulation of fibroblast proliferation
GO:0048511 rhythmic process
GO:0050821 protein stabilization
GO:0055025 positive regulation of cardiac muscle tissue development
GO:0060251 regulation of glial cell proliferation
GO:0060428 lung epithelium development
GO:0060430 lung saccule development
GO:0060509 Type I pneumocyte differentiation
GO:0071294 cellular response to zinc ion
GO:0071363 cellular response to growth factor stimulus
GO:0071398 cellular response to fatty acid
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:1900273 positive regulation of long-term synaptic potentiation
GO:1901215 negative regulation of neuron death
GO:1902065 response to L-glutamate
GO:1990090 cellular response to nerve growth factor stimulus
GO:1990314 cellular response to insulin-like growth factor stimulus
GO:1990830 cellular response to leukemia inhibitory factor

Cellular Component:
GO:0000785 chromatin
GO:0000790 nuclear chromatin
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription factor complex
GO:0005719 nuclear euchromatin
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0030424 axon
GO:1990589 ATF4-CREB1 transcription factor complex


-  Descriptions from all associated GenBank mRNAs
  AK312747 - Homo sapiens cDNA, FLJ93156, Homo sapiens cAMP responsive element binding protein 1 (CREB1),transcript variant B, mRNA.
LF205222 - JP 2014500723-A/12725: Polycomb-Associated Non-Coding RNAs.
LF213835 - JP 2014500723-A/21338: Polycomb-Associated Non-Coding RNAs.
BC095407 - Homo sapiens cAMP responsive element binding protein 1, mRNA (cDNA clone MGC:110900 IMAGE:30344522), complete cds.
X55545 - Homo sapiens mRNA for CREB protein.
M27691 - Human transactivator protein (CREB) mRNA, complete cds.
BC010636 - Homo sapiens cAMP responsive element binding protein 1, mRNA (cDNA clone MGC:9284 IMAGE:3872792), complete cds.
AK298740 - Homo sapiens cDNA FLJ56700 complete cds, highly similar to cAMP response element-binding protein.
AY347527 - Homo sapiens CREB mRNA, complete cds.
AK315226 - Homo sapiens cDNA, FLJ96224, Homo sapiens cAMP responsive element binding protein 1 (CREB1),transcript variant A, mRNA.
MA440799 - JP 2018138019-A/12725: Polycomb-Associated Non-Coding RNAs.
MA449412 - JP 2018138019-A/21338: Polycomb-Associated Non-Coding RNAs.
JD136829 - Sequence 117853 from Patent EP1572962.
JD180853 - Sequence 161877 from Patent EP1572962.
LF212826 - JP 2014500723-A/20329: Polycomb-Associated Non-Coding RNAs.
JD240487 - Sequence 221511 from Patent EP1572962.
LF318185 - JP 2014500723-A/125688: Polycomb-Associated Non-Coding RNAs.
MA448403 - JP 2018138019-A/20329: Polycomb-Associated Non-Coding RNAs.
MA553762 - JP 2018138019-A/125688: Polycomb-Associated Non-Coding RNAs.
CU679771 - Synthetic construct Homo sapiens gateway clone IMAGE:100019015 5' read CREB1 mRNA.
AB385549 - Synthetic construct DNA, clone: pF1KB5414, Homo sapiens CREB1 gene for cAMP response element-binding protein, complete cds, without stop codon, in Flexi system.
CR407617 - Homo sapiens full open reading frame cDNA clone RZPDo834B062D for gene CREB1, cAMP responsive element binding protein 1 complete cds, without stopcodon.
DQ894336 - Synthetic construct Homo sapiens clone IMAGE:100008796; FLH169826.01L; RZPDo839G0895D cAMP responsive element binding protein 1 (CREB1) gene, encodes complete protein.
BT019509 - Homo sapiens cAMP responsive element binding protein 1 mRNA, complete cds.
DQ891157 - Synthetic construct clone IMAGE:100003787; FLH169830.01X; RZPDo839G0896D cAMP responsive element binding protein 1 (CREB1) gene, encodes complete protein.
KJ890966 - Synthetic construct Homo sapiens clone ccsbBroadEn_00360 CREB1 gene, encodes complete protein.
M34356 - Human active transcription factor CREB mRNA, complete cds.
X60003 - Human delta CREB mRNA for cAMP-responsive element (CRE) binding protein.
LF318199 - JP 2014500723-A/125702: Polycomb-Associated Non-Coding RNAs.
AK302333 - Homo sapiens cDNA FLJ57667 complete cds, highly similar to cAMP response element-binding protein.
LF318200 - JP 2014500723-A/125703: Polycomb-Associated Non-Coding RNAs.
S78693 - alpha CREB-1=cyclic AMP response element-binding protein-1 alpha isoform {alternatively spliced, internal fragment} [human, placenta, mRNA Partial, 64 nt].
S78695 - alpha beta CREB-1=cyclic AMP response element-binding protein-1 alpha beta isoform {alternatively spliced, internal fragment} [human, placenta, mRNA Partial, 81 nt].
JD286222 - Sequence 267246 from Patent EP1572962.
JD297313 - Sequence 278337 from Patent EP1572962.
LF318204 - JP 2014500723-A/125707: Polycomb-Associated Non-Coding RNAs.
JD429537 - Sequence 410561 from Patent EP1572962.
LF318205 - JP 2014500723-A/125708: Polycomb-Associated Non-Coding RNAs.
JD183919 - Sequence 164943 from Patent EP1572962.
JD334025 - Sequence 315049 from Patent EP1572962.
JD528338 - Sequence 509362 from Patent EP1572962.
JD562697 - Sequence 543721 from Patent EP1572962.
JD093428 - Sequence 74452 from Patent EP1572962.
LF318206 - JP 2014500723-A/125709: Polycomb-Associated Non-Coding RNAs.
JD235366 - Sequence 216390 from Patent EP1572962.
JD160403 - Sequence 141427 from Patent EP1572962.
JD561872 - Sequence 542896 from Patent EP1572962.
JD148622 - Sequence 129646 from Patent EP1572962.
JD179378 - Sequence 160402 from Patent EP1572962.
JD381259 - Sequence 362283 from Patent EP1572962.
JD044023 - Sequence 25047 from Patent EP1572962.
JD482036 - Sequence 463060 from Patent EP1572962.
JD499659 - Sequence 480683 from Patent EP1572962.
JD286713 - Sequence 267737 from Patent EP1572962.
JD511545 - Sequence 492569 from Patent EP1572962.
JD319539 - Sequence 300563 from Patent EP1572962.
JD319540 - Sequence 300564 from Patent EP1572962.
JD105752 - Sequence 86776 from Patent EP1572962.
JD071050 - Sequence 52074 from Patent EP1572962.
JD119120 - Sequence 100144 from Patent EP1572962.
JD278366 - Sequence 259390 from Patent EP1572962.
JD144694 - Sequence 125718 from Patent EP1572962.
JD085874 - Sequence 66898 from Patent EP1572962.
JD337206 - Sequence 318230 from Patent EP1572962.
JD205971 - Sequence 186995 from Patent EP1572962.
JD344625 - Sequence 325649 from Patent EP1572962.
JD443377 - Sequence 424401 from Patent EP1572962.
AK126342 - Homo sapiens cDNA FLJ44370 fis, clone TRACH3008902.
LF318207 - JP 2014500723-A/125710: Polycomb-Associated Non-Coding RNAs.
AK123952 - Homo sapiens cDNA FLJ41958 fis, clone PUAEN2001345.
LF318208 - JP 2014500723-A/125711: Polycomb-Associated Non-Coding RNAs.
LF318210 - JP 2014500723-A/125713: Polycomb-Associated Non-Coding RNAs.
LF318211 - JP 2014500723-A/125714: Polycomb-Associated Non-Coding RNAs.
AK091534 - Homo sapiens cDNA FLJ34215 fis, clone FCBBF3021985.
LF318212 - JP 2014500723-A/125715: Polycomb-Associated Non-Coding RNAs.
AK095116 - Homo sapiens cDNA FLJ37797 fis, clone BRSSN1000153.
MA553776 - JP 2018138019-A/125702: Polycomb-Associated Non-Coding RNAs.
MA553777 - JP 2018138019-A/125703: Polycomb-Associated Non-Coding RNAs.
MA553781 - JP 2018138019-A/125707: Polycomb-Associated Non-Coding RNAs.
MA553782 - JP 2018138019-A/125708: Polycomb-Associated Non-Coding RNAs.
MA553783 - JP 2018138019-A/125709: Polycomb-Associated Non-Coding RNAs.
MA553784 - JP 2018138019-A/125710: Polycomb-Associated Non-Coding RNAs.
MA553785 - JP 2018138019-A/125711: Polycomb-Associated Non-Coding RNAs.
MA553787 - JP 2018138019-A/125713: Polycomb-Associated Non-Coding RNAs.
MA553788 - JP 2018138019-A/125714: Polycomb-Associated Non-Coding RNAs.
MA553789 - JP 2018138019-A/125715: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04612 - Antigen processing and presentation
hsa04916 - Melanogenesis
hsa04962 - Vasopressin-regulated water reabsorption
hsa05016 - Huntington's disease
hsa05215 - Prostate cancer

BioCarta from NCI Cancer Genome Anatomy Project
h_carm1Pathway - Transcription Regulation by Methyltransferase of CARM1
h_hifPathway - Hypoxia-Inducible Factor in the Cardiovascular System
h_melanocytepathway - Melanocyte Development and Pigmentation Pathway
h_crebPathway - Transcription factor CREB and its extracellular signals
h_CaCaMPathway - Ca++/ Calmodulin-dependent Protein Kinase Activation
h_HuntingtonPathway - Inhibition of Huntington's disease neurodegeneration by histone deacetylase inhibitors
h_dreampathway - Repression of Pain Sensation by the Transcriptional Regulator DREAM
h_HBxPathway - Calcium Signaling by HBx of Hepatitis B virus
h_hcmvPathway - Human Cytomegalovirus and Map Kinase Pathways
h_mapkPathway - MAPKinase Signaling Pathway
h_erk5Pathway - Role of Erk5 in Neuronal Survival
h_gpcrPathway - Signaling Pathway from G-Protein Families
h_p38mapkPathway - p38 MAPK Signaling Pathway
h_arenrf2Pathway - Oxidative Stress Induced Gene Expression Via Nrf2

Reactome (by CSHL, EBI, and GO)

Protein P16220 (Reactome details) participates in the following event(s):

R-HSA-111912 CaMK IV phosphorylates CREB
R-HSA-111919 PKA phosphorylates CREB
R-HSA-199298 AKT phosphorylates CREB1
R-HSA-199895 RSK1/2/3 phosphorylates CREB at Serine 133
R-HSA-199917 MAPKAPK2 phosphorylates CREB at Serine 133
R-HSA-199935 MSK1 activates CREB
R-HSA-442724 Phosphorylation of CREB by ribosomal protein S6 kinase
R-HSA-443474 Phosphorylation of CREB by PKA
R-HSA-443475 Phosphorylation of CREB by CaMKII
R-HSA-443480 Phosphorylation of CREB by CaMKIV
R-HSA-2399996 AKT1 E17K mutant phosphorylates CREB1
R-HSA-111916 Dimerisation of CREB
R-HSA-2976563 NOTCH2 coactivator complex and phosphorylated CREB1 bind GZMB promoter
R-HSA-111932 CaMK IV-mediated phosphorylation of CREB
R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis
R-HSA-111931 PKA-mediated phosphorylation of CREB
R-HSA-198693 AKT phosphorylates targets in the nucleus
R-HSA-199920 CREB phosphorylation
R-HSA-881907 Gastrin-CREB signalling pathway via PKC and MAPK
R-HSA-375165 NCAM signaling for neurite out-growth
R-HSA-442742 CREB phosphorylation through the activation of Ras
R-HSA-442720 CREB phosphorylation through the activation of Adenylate Cyclase
R-HSA-442729 CREB phosphorylation through the activation of CaMKII
R-HSA-442717 CREB phosphorylation through the activation of CaMKK
R-HSA-5674400 Constitutive Signaling by AKT1 E17K in Cancer
R-HSA-2197563 NOTCH2 intracellular domain regulates transcription
R-HSA-111933 Calmodulin induced events
R-HSA-1592230 Mitochondrial biogenesis
R-HSA-1257604 PIP3 activates AKT signaling
R-HSA-198725 Nuclear Events (kinase and transcription factor activation)
R-HSA-450282 MAPK targets/ Nuclear events mediated by MAP kinases
R-HSA-416476 G alpha (q) signalling events
R-HSA-422475 Axon guidance
R-HSA-438064 Post NMDA receptor activation events
R-HSA-2219528 PI3K/AKT Signaling in Cancer
R-HSA-1980145 Signaling by NOTCH2
R-HSA-111997 CaM pathway
R-HSA-1852241 Organelle biogenesis and maintenance
R-HSA-9006925 Intracellular signaling by second messengers
R-HSA-187037 Signaling by NTRK1 (TRKA)
R-HSA-450294 MAP kinase activation
R-HSA-388396 GPCR downstream signalling
R-HSA-1266738 Developmental Biology
R-HSA-442755 Activation of NMDA receptor and postsynaptic events
R-HSA-5663202 Diseases of signal transduction
R-HSA-157118 Signaling by NOTCH
R-HSA-111996 Ca-dependent events
R-HSA-1489509 DAG and IP3 signaling
R-HSA-162582 Signal Transduction
R-HSA-166520 Signaling by NTRKs
R-HSA-166058 MyD88:Mal cascade initiated on plasma membrane
R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade
R-HSA-448424 Interleukin-17 signaling
R-HSA-937061 TRIF(TICAM1)-mediated TLR4 signaling
R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
R-HSA-975871 MyD88 cascade initiated on plasma membrane
R-HSA-372790 Signaling by GPCR
R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission
R-HSA-1643685 Disease
R-HSA-112043 PLC beta mediated events
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade
R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade
R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade
R-HSA-168898 Toll-Like Receptors Cascades
R-HSA-449147 Signaling by Interleukins
R-HSA-166166 MyD88-independent TLR4 cascade
R-HSA-975155 MyD88 dependent cascade initiated on endosome
R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade
R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade
R-HSA-112315 Transmission across Chemical Synapses
R-HSA-112040 G-protein mediated events
R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade
R-HSA-168249 Innate Immune System
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade
R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade
R-HSA-112316 Neuronal System
R-HSA-111885 Opioid Signalling
R-HSA-168256 Immune System
R-HSA-418594 G alpha (i) signalling events

-  Other Names for This Gene
  Alternate Gene Symbols: CREB1_HUMAN, NM_134442, NP_604391, P16220, P21934, Q6V963, Q9UMA7
UCSC ID: uc002vcc.3
RefSeq Accession: NM_134442
Protein: P16220 (aka CREB1_HUMAN)
CCDS: CCDS2374.1, CCDS2375.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_134442.3
exon count: 9CDS single in 3' UTR: no RNA size: 9794
ORF size: 1026CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2237.00frame shift in genome: no % Coverage: 99.85
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.