Description: Homo sapiens chemokine (C-C motif) receptor 3 (CCR3), transcript variant 3, mRNA. RefSeq Summary (NM_178328): The protein encoded by this gene is a receptor for C-C type chemokines. It belongs to family 1 of the G protein-coupled receptors. This receptor binds and responds to a variety of chemokines, including eotaxin (CCL11), eotaxin-3 (CCL26), MCP-3 (CCL7), MCP-4 (CCL13), and RANTES (CCL5). It is highly expressed in eosinophils and basophils, and is also detected in TH1 and TH2 cells, as well as in airway epithelial cells. This receptor may contribute to the accumulation and activation of eosinophils and other inflammatory cells in the allergic airway. It is also known to be an entry co-receptor for HIV-1. This gene and seven other chemokine receptor genes form a chemokine receptor gene cluster on the chromosomal region 3p21. Alternatively spliced transcript variants have been described. [provided by RefSeq, Sep 2009]. Transcript (Including UTRs) Position: hg19 chr3:46,283,872-46,308,197 Size: 24,326 Total Exon Count: 3 Strand: + Coding Region Position: hg19 chr3:46,305,895-46,307,717 Size: 1,823 Coding Exon Count: 2
ID:F5GWL6_HUMAN DESCRIPTION: SubName: Full=C-C chemokine receptor type 3; SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.
asthma Fukunaga, K. et al. 2001, Genetic polymorphisms of CC chemokine receptor 3 in Japanese and British asthmatics., The European respiratory journal. 2001 Jan;17(1):59-63.
[PubMed 11307756]
In conclusion, a significant association between asthma and CCR3 T51C polymorphism localized on chromosome 3p21 was found.
Asthma Fukunaga K 2001, Genetic polymorphisms of CC chemokine receptor 3 in Japanese and British asthmatics., The European respiratory journal. 2001 Jan;17(1):59-63.
[PubMed 11307756]
In conclusion, a significant association between asthma and CCR3 T51C polymorphism localized on chromosome 3p21 was found.
Asthma Fukunaga K 2001, Genetic polymorphisms of CC chemokine receptor 3 in Japanese and British asthmatics., The European respiratory journal. 2001 Jan;17(1):59-63.
[PubMed 11307756]
In conclusion, a significant association between asthma and CCR3 T51C polymorphism localized on chromosome 3p21 was found.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
SCOP Domains: 81321 - Family A G protein-coupled receptor-like
ModBase Predicted Comparative 3D Structure on F5GWL6
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AK123050 - Homo sapiens cDNA FLJ41055 fis, clone SYNOV2000601, highly similar to C-C CHEMOKINE RECEPTOR TYPE 3. BC033514 - Homo sapiens cDNA clone IMAGE:5176960, **** WARNING: chimeric clone ****. AF262300 - Homo sapiens clone 2 CC chemokine receptor 3 (CCR3) mRNA, partial cds. AF262299 - Homo sapiens clone 1 CC chemokine receptor 3 (CCR3) mRNA, partial cds. AX513223 - Sequence 22 from Patent WO02062848. AX513222 - Sequence 21 from Patent WO02062848. AF224495 - Homo sapiens CC chemokine receptor 3 (CCR3) mRNA, partial cds. AF262301 - Homo sapiens clone 4 CC chemokine receptor 3 (CCR3) mRNA, partial cds. AF262302 - Homo sapiens clone 5 CC chemokine receptor 3 (CCR3) mRNA, partial cds. AF262304 - Homo sapiens clone 7 CC chemokine receptor 3-like mRNA, partial sequence, alternatively spliced. AF262303 - Homo sapiens clone 6 CC chemokine receptor 3 (CCR3) mRNA, partial cds. BC130318 - Homo sapiens chemokine (C-C motif) receptor 3, mRNA (cDNA clone MGC:163190 IMAGE:40146349), complete cds. BC130320 - Homo sapiens chemokine (C-C motif) receptor 3, mRNA (cDNA clone MGC:163192 IMAGE:40146351), complete cds. AX513224 - Sequence 23 from Patent WO02062848. BC110297 - Homo sapiens chemokine (C-C motif) receptor 3, mRNA (cDNA clone MGC:102841 IMAGE:5212541), complete cds. AX513225 - Sequence 24 from Patent WO02062848. U28694 - Human eosinophil CC chemokine receptor 3 mRNA, complete cds. AB464481 - Synthetic construct DNA, clone: pF1KB8807, Homo sapiens CCR3 gene for chemokine (C-C motif) receptor 3, without stop codon, in Flexi system. KJ890938 - Synthetic construct Homo sapiens clone ccsbBroadEn_00332 CCR3 gene, encodes complete protein. AF026535 - Homo sapiens chemokine receptor (CCR3) mRNA, complete cds. HQ258185 - Synthetic construct Homo sapiens clone IMAGE:100072494 chemokine (C-C motif) receptor 3 (CCR3), transcript variant 2 (CCR3) gene, encodes complete protein. JD303145 - Sequence 284169 from Patent EP1572962. JD092255 - Sequence 73279 from Patent EP1572962. JD184708 - Sequence 165732 from Patent EP1572962. JD316195 - Sequence 297219 from Patent EP1572962. JD266963 - Sequence 247987 from Patent EP1572962. JD501050 - Sequence 482074 from Patent EP1572962.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa04060 - Cytokine-cytokine receptor interaction hsa04062 - Chemokine signaling pathway
BioCarta from NCI Cancer Genome Anatomy Project h_nktPathway - Selective expression of chemokine receptors during T-cell polarization h_CCR3Pathway - CCR3 signaling in Eosinophils h_eosinophilsPathway - The Role of Eosinophils in the Chemokine Network of Allergy h_il5Pathway - IL 5 Signaling Pathway