Description: Homo sapiens caspase 7, apoptosis-related cysteine peptidase (CASP7), transcript variant f, mRNA. RefSeq Summary (NM_001267057): This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. The precursor of the encoded protein is cleaved by caspase 3 and 10, is activated upon cell death stimuli and induces apoptosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]. Transcript (Including UTRs) Position: hg19 chr10:115,439,428-115,490,668 Size: 51,241 Total Exon Count: 7 Strand: + Coding Region Position: hg19 chr10:115,439,514-115,489,299 Size: 49,786 Coding Exon Count: 7
diabetes, type 1 Babu SR et al. 2003, Caspase 7 is a positional candidate gene for IDDM 17 in a Bedouin Arab family., Annals of the New York Academy of Sciences. 2003 Nov;1005:340-3.
[PubMed 14679087]
esophageal adenocarcinoma Liu CY et al. 2010, A Large Scale Genetic Association Study of Esophageal Adenocarcinoma Risk., Carcinogenesis 31(7) : 1259-63 2010.
[PubMed 20453000]
, this study suggests that the genetic variants of CASP7 and CASP9 in the apoptosis pathway may be important predictive markers for EA susceptibility and that PGR in the sex hormone signaling pathway may be associated with the gender differences in EA risk.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on B4DQU7
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
