Description: Homo sapiens beclin 1, autophagy related (BECN1), mRNA. RefSeq Summary (NM_003766): This gene encodes a protein that regulates autophagy, a catabolic process of degradation induced by starvation. The encoded protein is a component of the phosphatidylinositol-3-kinase (PI3K) complex which mediates vesicle-trafficking processes. This protein is thought to play a role in multiple cellular processes, including tumorigenesis, neurodegeneration and apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]. Transcript (Including UTRs) Position: hg19 chr17:40,962,150-40,976,310 Size: 14,161 Total Exon Count: 12 Strand: - Coding Region Position: hg19 chr17:40,962,778-40,975,895 Size: 13,118 Coding Exon Count: 11
ID:BECN1_HUMAN DESCRIPTION: RecName: Full=Beclin-1; AltName: Full=Coiled-coil myosin-like BCL2-interacting protein; AltName: Full=Protein GT197; FUNCTION: Plays a central role in autophagy. Required for the abcission step in cytokinesis. May play a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus. SUBUNIT: Interacts with GOPC and GRID2. Interacts with AMBRA1. Forms a complex with PIK3C3 and PIK3R4 and either UVRAG and KIAA0226/Rubicon, or with ATG14. UVRAG and ATG14 form mutually exclusive complexes through direct competition for BECN1-binding. The complex containing ATG14 up-regulates autophagy, while the one containing Rubicon down-regulates autophagy (By similarity). Interacts with BCL2 and BCL2L1. Interacts with VMP1. Interacts with PIK3CB (By similarity). Interacts with DAPK1. Interacts with human cytomegalovirus/HHV-5 protein TRS1. INTERACTION: P10415:BCL2; NbExp=3; IntAct=EBI-949378, EBI-77694; Q07817-1:BCL2L1; NbExp=4; IntAct=EBI-949378, EBI-287195; Q8IYI6:EXOC8; NbExp=4; IntAct=EBI-949378, EBI-742102; Q8NEB9:PIK3C3; NbExp=6; IntAct=EBI-949378, EBI-1056470; SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Note=Interaction with ATG14 promotes translocation to autophagosomes. Expressed in dendrites and cell bodies of cerebellar Purkinje cells (By similarity). TISSUE SPECIFICITY: Ubiquitous. PTM: Phosphorylation at Thr-119 by DAPK1 reduces its interaction with BCL2 and BCL2L1 and promotes induction of autophagy. PTM: Ubiquitinated. Deubiquitinated by USP10 and USP13, leading to stabilize the PIK3C3/VPS34-containing complexes. SIMILARITY: Belongs to the beclin family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q14457
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005515 protein binding GO:0019901 protein kinase binding GO:0031625 ubiquitin protein ligase binding GO:0042803 protein homodimerization activity GO:0043548 phosphatidylinositol 3-kinase binding GO:0051020 GTPase binding
Biological Process: GO:0000045 autophagosome assembly GO:0000422 mitophagy GO:0000423 macromitophagy GO:0001666 response to hypoxia GO:0006897 endocytosis GO:0006914 autophagy GO:0006915 apoptotic process GO:0006968 cellular defense response GO:0006995 cellular response to nitrogen starvation GO:0007040 lysosome organization GO:0007049 cell cycle GO:0007080 mitotic metaphase plate congression GO:0007568 aging GO:0008285 negative regulation of cell proliferation GO:0010040 response to iron(II) ion GO:0010288 response to lead ion GO:0010507 negative regulation of autophagy GO:0010508 positive regulation of autophagy GO:0010613 positive regulation of cardiac muscle hypertrophy GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling GO:0016032 viral process GO:0016236 macroautophagy GO:0016579 protein deubiquitination GO:0031667 response to nutrient levels GO:0032465 regulation of cytokinesis GO:0032801 receptor catabolic process GO:0033197 response to vitamin E GO:0034198 cellular response to amino acid starvation GO:0042149 cellular response to glucose starvation GO:0042493 response to drug GO:0043066 negative regulation of apoptotic process GO:0043652 engulfment of apoptotic cell GO:0044804 nucleophagy GO:0045022 early endosome to late endosome transport GO:0045324 late endosome to vacuole transport GO:0048666 neuron development GO:0050435 beta-amyloid metabolic process GO:0050790 regulation of catalytic activity GO:0051301 cell division GO:0051607 defense response to virus GO:0051707 response to other organism GO:0060548 negative regulation of cell death GO:0070301 cellular response to hydrogen peroxide GO:0071275 cellular response to aluminum ion GO:0071280 cellular response to copper ion GO:0071364 cellular response to epidermal growth factor stimulus GO:0098780 response to mitochondrial depolarisation GO:1902425 positive regulation of attachment of mitotic spindle microtubules to kinetochore GO:1902902 negative regulation of autophagosome assembly GO:1905672 negative regulation of lysosome organization GO:2000378 negative regulation of reactive oxygen species metabolic process GO:2000786 positive regulation of autophagosome assembly GO:0032258 CVT pathway
US Server
